Center for Relativistic Laser Science

Major Experience

1991-1996  Senior Research Scientist, Research Center of Chong Kun Dang Pharmaceutical Company, Seoul, Korea

ž2001-2003  Postdoctoral Fellow, Department of Pathology Harvard Medical School

ž2004-2008  Assistant Professor, School of Life Sciences, Gwangju Institute of Science and Technology (GIST)

ž2008-2012  Associate Professor, School of Life Sciences, Gwangju Institute of Science and Technology (GIST)

ž2012-2013  Professor, School of Life Sciences, Gwangju Institute of Science and Technology (GIST)

ž2014~present  Professor, Division of Integrative Biosciences and Biotechnology, POSTECH

Research Interests

žRole of transcription factors (Ets1 and NFAT1) in immune regulation and tolerance

žMolecular mechanism of IL-10 gene regulation in lymphocytes and dendritic cells

žElucidation of the signaling pathways for IL-10 expression induced by commensal bacteria and probiotics.

žElucidation of the mechanism of probiotics-induced immune modulation

žCharacterization of regulatory DCs and regulatory T cells (iTreg) cells induced by probiotics

žDevelopment of antigen-specific immunotherapy for autoimmune disorders (Myasthenia gravis and rheumatoid arthritis)

Selected Publications

1. Kwon HK, Kim GC, Kim Y, Hwang W, Jash A, Sahoo A Nam JH, and Im SH. Amelioration of experimental autoimmune encephalomyelitis by probiotics mixture is mediated by a shift in T helper cell immune response. Clinical Immunology. 2013;146(3):217-227

2. Chae CS, Kwon HK, Hwang JS, Im SH. Prophylactic effect of probiotics on the development of experimental autoimmune myasthenia gravis. PLoS One. 2012;7(12):e52119

3. Lee IH, Kwon HK, An S, Kim D, Kim S, Yu MK, Lee JH, Lee TS, Im SH, Jon S. Imageable Antigen-Presenting Gold Nanoparticle Vaccines for Effective Cancer Immunotherapy In Vivo. Angew Chem Int Ed Engl. 2012;51(35):8800-5

4. Jash A, Sahoo A, Kim GC, Chae CS, Hwang JS, Kim JE, ImSH. NFAT induced permissive chromatin modification facilitates NF-κB mediated interleukin-9 (IL-9) transactivation. J Biol Chem. 2012;287(19):15445-57

5. Jash A, Yun KS, Sahoo A, So JS, Im SH. Looping mediated interaction between the promoter and 3′ UTR regulates type II collagen expression in chondrocytes. PLoS One. 2012;7(7):e40828.

6. Lee CG, Kwon HK, Sahoo A, Won H, So JS, Hwang JS, Chae CS, Kim GC, So HS, Hwang ES, Grenningloh R, Ho IC and ImSH. Interaction of Ets-1 with HDAC1 represses IL-10 expression in T helper 1 cells. J Immunol. 2012;188(5):2244-253

7. Son JS, Chae CS, Hwang JS, Park ZY, Im SH. Enhanced chromatin accessibility and recruitment of JUNB mediate the sustained IL-4 expression in NFAT1 deficient T helper 2 cells. PLoS One. 2011. 6(7): e22042

8. Lee IH, An S, Yu MK, Kwon HK, Im SH, Jon S. Targeted chemoimmunotherapy using drug-loaded aptamer-dendrimer bioconjugates. J Control Release. 2011; 155(3):435-41

9. Sahoo A, Lee CG, Jash A, Son JS, Kim G, Kwon HK, So JS, Im SH. Stat6 and c-Jun Mediate Th2 Cell-Specific IL-24 Gene Expression. J Immunol. 2011;186(7):4098-109

10. So JS, Song MK, Kwon HK a, Lee CG, Chae CS, Sahoo A, Jash A, Lee SH, Park ZY and Im SH. Lactobacillus casei enhances type II collagen/glucosamine-mediated suppression of inflammatory responses in experimental osteoarthritis. Life Sci. 2011;88(7-8):358-66

11. Kwon HK, Lee CG, Jae-Seon Soa, Chae CS, Hwang JS, Sahoo A, Nam JH, Rhee JH, Hwang KC, and Im SH Generation of regulatory dendritic cells and CD4+Foxp3+ T cells by probiotics administration suppresses immune disorders; Proc Natl Acad Sci U S A. 2010;107(5):2159-64. Commented by J Allergy Clin Immunol . May 2010. Page 953

12. Sahoo A and Im SH Interleukin and Interleukin Receptor Diversity: Role of Alternative Splicing. Int Rev Immunol. 2010;29(1):77-109

13. Lee CG, Won H, Maeng KE, Kwon HK, So JS, Sahoo A, Lee SH, Park ZY, ImSH. IRF4 regulates IL-10 gene expression in CD4+ T cells through differential nuclear translocation. Cell Immunol 2011;268: 97-104

14. Yun KS, So JS, Jash A and Im SH Lef1 regulates transcription through gene looping. J Immunol 2009 Oct 15;183(8):5129-37

15. CG Lee, KH Kang, JS So, HK Kwon, JS Son, MK Song, A Sahoo, HJ Yi, KC Hwang, T Matsuyama, K Yui, SH Im. A distal cis-regulatory element, CNS-9, controls NFAT1 and IRF4-mediated IL-10 gene activation in T helper cells. Mol Immunol. 2009 Feb;46(4):613-21

16. Kwon HK, Jeon WK, Hwang JS, Lee CG, So JS, Park JA, Ko BS, Im SH. Cinnamon extract suppresses tumor progression by modulating angiogenesis and the effector function of CD8(+) T cells. Cancer Lett. 2009; 278(2): 174-182

17. Lee CG, Kang KH, So JS, Kwon HK, JS Son JS, Song MK, Sahoo A, HJ HJ, KC Hwang, Matsuyama T, Yui K, Im SH. A distal cis-regulatory element, CNS-9, controls NFAT1 and IRF4-mediated IL-10 gene activation in T helper cells. Mol Immunol. 2009;46(4):613-21

18. Sahoo A, Jung YM, Kwon HK, Yi HJi, Lee S, Chang S, Park ZY, Hwang KC, Im SH. A novel splicing variant of mouse IL-24 antagonizes IL-24-induced apoptosis. J Biol Chem. 2008. 43: 28860-28872.

19. Yi HJ, CS Chae, JS So, ST Tzartos, MC Souroujon, S Fuchs, SH Im. Suppression of Experimental Myasthenia Gravis by a B-cell Epitope-Free Recombinant Acetylcholine Receptor. Mol Immunol. 2008.09.15. 46(1):192-201

20. So JS, CG Lee, HK Kwon ,HJ Yi, CS Chae, JA Park, KC Hwang, SH Im. Lactobacillus casei potentiate induction of oral tolerance in experimental arthritis. Mol Immunol. 2008.09.18. 46(1):172-180

21. So JS, HK Kwon, CG Lee, HJ Yi, JA Park, SY Lim, KC Hwang, YH Jeon, SH Im. Lactobacillus casei suppresses experimental arthritis by down-regulating T helper 1 effector functions. Mol Immunol. 2008.02.19. 45(9):2690-2699

Education

2005     Ph.D, Cell Biology, Albert Einstein College of Medicine, NY

1998     Post M.Sc. Diploma, Center for Biotechnology, Jawaharlal Nehru University, New Delhi, India

1997     M.Sc. Department of Biochemistry, University of Calcutta, India

1995     B.Sc. Department of Chemistry, University of Calcutta, India

Research Experience

2009-2013:  Research Fellow in the laboratory of Dr. Alexander Rudensky, Memorial Slogan-Kettering Cancer Center

2006-2008:  Senior Fellow in the laboratory of Dr. Alexander Rudensky, University of Washington, Seattle

1999-2005:  PhD student in Cell Biology Department in the laboratory of Dr. Jonathan R. Warner, Albert Einstein College of Medicine, Bronx, NY

Honors

2013       Wellcome Trust/ DBT India Alliance Intermediate fellowship

2011      Best Poster Presentation Award-- Immunology and Microbial Pathogenesis Graduate Program Retreat, Weill Cornell Graduate School of Medical Sciences

2007- 2010  Arthritis Foundation Postdoctoral fellowship

2009       Selected to attend RIKEN Research Center for allergy and Immunology (RCAI) summer program 2009, Yokohama, Japan

1997-1998  Post-M.Sc. Fellowship from the Center for Biotechnology, Jawaharlal Nehru University, New Delhi, India

1997      Shanti Bhakta Memorial Award for best paper presentation, Dept. of Biochemistry, University of Calcutta

Education and Training

1990 - 1996  B.S., Department of Biological Sciences, College of Natural Sciences,

Chonnam National University, Gkwangju, Korea

1998        M.S., Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, Gyungbuk, Korea

2002        Ph.D., Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, Gyungbuk, Korea

Professional Experiences

2002 - 2003   Postdoctoral fellow, Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, Kyungbuk, Korea

2003 - 2006  Postdoctoral fellow, Department of Immunology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA

2006 - 2010    Research Officer, Immunology Research Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia

2010 -         Senior Research Officer, Immunology Research Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia

2010 -         Visiting Assistant Professor, WCU Program, Division of Integrative Biosciences and Biotechnology, POSTECH, Pohang, Gyungbuk, Korea

Funding

Australian National Health and Medical Research Council (NHMRC) Project Grant; funded from 2011 till 2013 as a chief investigator

 Research Assistant in Immune Regulation and Tolerance Lab.(Prof. Sin-Hyeog Im)

 Research Assistant in Immune Regulation and Tolerance Lab.(Prof. Sin-Hyeog Im) 

Research interests:

- Axion detecting experiment with interaction between particles

- Theoretical high energy physics

Team

Mouse TG

The Founding Member of PCS

◆ Education ­

 - Ph.D. in Chemistry, California Institute of Technology, USA (2001.06) (Graduate Advisor: Prof. Ahmed H. Zewail) ­

 - M.S. in Chemistry, California Institute of Technology, USA ­

 - B.S. in Chmistry, KAIST, Korea (1994.02)

◆ Experience ­

 - Assiciate Director, Center for Nanomaterials and Chemical Reactions, IBS (2015.07-present) ­

 - Group Leader, Center for Nanomaterials and Chemical Reactions, IBS (2012.11-2015.06) ­ 

 - Professor, Department of Chemistry, KAIST, Korea (2009.03-present) ­

 - Associate Professor, Department of Chemistry, KAIST, Korea (2006.03-2009.02) ­

 - Assistant Professor, Department of Chemistry, KAIST, Korea (2003.09-2006.02) ­

 - Director, Center for Time-Resolved Diffraction (2007.05-2012.11) ­

 - Postdoctoral Scholar (Prof. K. Moffat), Department of Biochemistry & Molecular Biology, University of Chicago, USA (2001.12-2003.07) ­

 - Postdoctoral Scholar (Prof. A. H. Zewail), Department of Chemistry, California Institute of Technolohy, USA (2001.06-2001.11)

◆ Education ­

 - Ph.D. Physics, Seoul National University (1999) ­

 - M.S. Physics, Seoul National University (1995) ­

 - B.S. Physics, Seoul National University (1993)

◆ Experience ­

 - Professor, KAIST, Department of Chemistry & Graduate School of EEWS (2017.03-Present)

 - Associate Director, Center for Nanomaterials and Chemical Reaction, IBS (2016.09-Present)

 - KAIST, Graduate School of EEWS Associate Professor (2009.08–2017.02)

 - Group Leader, Center for Nanomaterials and Chemical Reaction, IBS (2013.09- 2016.08)

 - Staff Scientist, Lawrence Berkeley National Laboratory (2006-2009)

 - Physicist Postdoctoral Fellow Lawrence Berkeley National Laboratory (2002-2006)

 - Postdoctoral Research Associate, University of Maryland, College Park, Department of Physics (1999-2002)

Time-resolved spectroscopy (Team1)

Pump-probe Spectroscopic Experiment

- The nitrile stretching vibrations in the cyanophenols
- The N3 stretching vibration in 4-azidoprolines
- The study of nitrile and thiocyanate in customized peptides for the IR probe

Ultrafast 2D IR Vibrational Echo Spectroscopic Experiment

- Puckering dynamics of 4S-azidoproline

Time-resolved spectroscopy (Team1)

- Time-resoleved vibrational spectroscopy, ultrafast two-dimensional infrared (2D-IR) spectroscopy

- Dynamics of ions and molecules in electrolytes and protein

Time-resolved Spectroscopy (Team1)

Dielectric relaxation and vibrational spectroscopic studies in ion conducting polymer electrolytes

- Polymer electrolytes for rechargeable lithium battery

- Fabication of polymer electrolytes film

- Understanding and improvement of charge transport behaviour in polymer electrolytes

Optical frequency comb spectroscopy (Team2)

- Transient absorption spectroscopy

- Frequency comb spectroscopy and asynchronous optical sampling

Optical frequency comb spectroscopy (Team2)

- Dual frequency comb spectroscopy

- Quantum spectroscopy/ quantum imaging

Computational chemistry (Team3)

- Theoretical modeling and simulation of solvation and ion transport in electrolyte solutions

- Theoretical description of nonlinear optical spectroscopy

Computational chemistry (Team3)

- Development of the machine learning potentials for aqueous electrolytes.

- Modeling of electrolyte solutions for rechargeable batteries for renewable energy storage.

Computational chemistry (Team3)

- To develop the first-principles machine learning potential that can be used to perform molecular dynamic simulations at the first-principles level of  accuracy.

- Sum frequency generation spectroscopy simulation of graphenee and water system.

Computational chemistry (Team3)

- Modeling Ionic Conductivities and Li-ion transport mechanism in Solid Polymer Electrolytes

- Investigation of the Role of Internal Rotation on the Anisotropy Decay of Vibrational Probe in Polymer Matrix

- Modeling Separator-Electrolyte Interactions Used in Lithium Ion Batteries

Computational chemistry (Team3)

- MD simulation study of self-assembled monolayers (SAMs) on noble metals surface.

Label-Free Imaging (Team4)

- Label-free, long-term live-cell imaging with interferometric scattering (iSCAT) microscopy

- Single-molecule biophysics using magentic tweezers system