Multifunctional Optoelectronics and Flexible Electronics
1. Printed Electronics (Printed single crystal silicon MOSFET& micro LED)
2. Bio-Integrated devices for Bio-medical Applications, Optogenetics
3. Wearable, skin electronics
Nano-materials and Nanoprocesses
1. Bio-inspired nanoscale sensors (or gecko lizard like Stooped nanohairs, Superhydrophobic (omniphobic) surface)
2. Development of Nanopatterning fabrcated by soft lithography, nano-imprint lithography
3. Wettability Control on Nano Strucutres (unidirectional wetting, micro fluidic channel)
1. D. Kang, P.V. Pikhitsa, Y.W. Choi, C. Lee, S.S. Shin, L. Piao, B. Park, K.-Y. Suh, Tae-il Kim*, M. Choi, "Ultransensitive mechanical crack-based sensor inspired by the spider sensory system", Nature 516: 222-226, 2014.
2. Tae-il Kim†, J.G. McCall†, Y.H. Jung, X, Huang, E. R. Siuda, Y. Li, J. Song, Y.M. Song, H.A. Pao, R. -H. Kim, Lu, S. D. Lee, I.-S. Song, G.C. Shin, R. Al-Hassani, S. Kim, M.P. Tan, Y. Huang, F.G. Omenetto, John.A. Rogers, M.R. Bruchas, "Injectable cellular scale optoelectronics with applications for wireless optogenetics", Science 340: 211-216, 2013.
3. Jordan McCall†, Tae-il Kim†, Gunchul Shin†, Xian Huang, Yei Hwan Jung, Fiorenzo G. Omenetto, Micheal R Bruchas, John A. Rogers, "Fabrication of flexible, multimodal light emitting devices for wireless optogenetics", Nat. Protoc. 8 2413-242, 2013.
4. Tae-il Kim†, C. Pang†, W. K. Bea, D.-S. Kang, S. M. Kim and K. Y. Suh, "Bioinspired Reversible Interlocker Using Regularly Arrayed High Aspect-Ratio Polymer Fibers", Adv. Mater. 24(4): 475-479, 2012. [selected as a front cover]
5. Tae-il Kim†, H.-J. Chung†, H.-S.Kim, S. A. Wells, S. Jo, N. Ahmed, Y. H. Jung, S. M. Won, C. A. Bower, John. A. Rogers, “Fabrication of releasable single crystal silicon metal oxide field effect devices and their assembly on foreign substrates”, Adv. Func. Mater. 21(16): 3029-3036, 2011. [selected as a front cover]
Lab Name: Cancer biology lab
Introduction
The DNA damage response (DDR) is essential for preserving genomic integrity in eukaryotes. At the start of the DDR network are the ATM and ATR kinases, which impose their regulation on multiple repair pathways via damage-induced phosphorylation. The overall goal of our laboratory is to understand the molecular mechanisms underlying genomic instability and tumorigenesis using DNA damage signaling pathway. The maintenance of genomic integrity following DNA damage depends on the interaction of DNA repair with cell cycle checkpoint controls. The integrity of the DNA damage response pathway is crucial for the prevention of neoplastic transformation, as suggested by the fact that many proteins involved in these pathways are tumor suppressors including p53, ATM, Chk2, RAP80, BRCA1 and BRCA2. Our group has discovered and studied many new components involved in DNA damage pathways. Recently, our group also studied other areas of genomic instability, including mitotic regulation. Our lab is also studying a signal transduction pathway in brain.
Selected Recent Publications
1. Lee NS, Chung HJ, Kim HJ, Lee SY, JJi J, Seo Y, Han SH, Choi M, Yun M, Lee SG, Myung K, Kim Y, Kang HC, Kim H, Nature communication, 2015.
2. Cho HJ, Oh YJ, Han SH, Chung HJ, Kim CH, Lee NS, Kim WJ, Choi JM, Kim H,"Cdk1 protein-mediated phosphorylation of receptor-associated protein 80 (RAP80) serine 677 modulates DNA damage-induced G2/M checkpoint and cell survival" J Biol Chem 8;288(6): 3768-76, 2013.
3. Kim H, Lee JE, Shin ES, Yoo YK, Cho JH, Yun MH, Kim YH, Kim SK, Kim HJ, Jang TW, Kwak SM, Kim CS, Ryu JS, "Effect of BRCA1 haplotype on survival of non-small-cell lung cancer patients treated with platinum-based chemotherapy", J Clin Oncol 26(36): 5972-5979, 2008.
4. Hongtae Kim, Jun Huang & Junjie Chen, "CCDC98 is a BRCA1-BRCT domain–binding protein involved in the DNA damage response", Nature structure& Molecular biology, 14: 710-715, 2007.
5. Hongtae Kim, Junjie Chen* and Xiaochun Yu* (*To whom correspondence should be addressed), "Ubiquitin-binding protein mediates BRCA1-dependent DNA damage responses", Science 316 : 1202-1205, 2007.
Since November, 2020
Office No. B437
Since August, 2021
Office No. B417
Since October, 2022
Office No. 428
Since October, 2022
Office No. 428
Since March, 2023
Office No. B413
Since September, 2023
Office No. 411
Since September, 2023
Office No. 437