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  • Zijun ZHOU
  • Research Fellow

  • NIU Kaikai
  • Research Fellow

  • Bumsu Park
  • Reserch assistant

  • Heejung Chun
  • Senior Researcher
  • Reactive astrocyte, Neurodegeneration, Oxidative stress, glia-neuron interaction
  • hjcibs.re.kr

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  • EDUCATION

    Undergraduate, 2001/3~2005/2, Biological Sciences, Korea University

    Graduate, 2005/8~2015/8, Interdisciplinary Program in Neuroscience, Seoul National University

    RESEARCH EXPERIENCES

    2010/7~2014/06, Researcher, KIST

    2014/07~2015/6, Visiting Graduate student, KIST

    2016/7-present, Post doctoral fellow, KIST

    EXPERICENED RESEARCH SKILLS

    Slice Patch (Neuron and Astrocyte), Immunohistochemistry, Confocal imaging, Behavioral Test (passive avoidance test, open field test, fear conditioning, elevated plus maze), Molecular Biological Techniques (Cloning, Subcloning and RT-PCR), Stereotaxic Surgery, Cell Culture (Primary astrocyte, Primary neuron, and Cell line)

    PUBLICATIONS

    1. Channel-mediated astrocytic glutamate modulates hippocampal synaptic plasticity by activating postsynaptic NMDA receptors. Park H, Han KS, Seo J, Lee J, Dravid SM, Woo J, Chun H, Cho S, Bae J, An H, Koh W, Yoon BE, Berlinguer-Palmini R, Mannaioni G, Traynelis SF, Bae Y, Choi SY, Lee C. Mol Brain. 2015 Feb 3;8(1):7 2. Glial GABA, synthesized by monoamine oxidase B, mediates tonic inhibition Bo-Eun Yoon, JunsungWoo, Ye-Eun Chun, Heejung Chun, Seonmi Jo, Jin Young Bae, Heeyoung An, JooOkMin, Soo-Jin Oh, Kyung-Seok Han, Hye Yun Kim, Taekeun Kim, Young Soo Kim, Yong Chul Bae and C. Justin Lee. J Physiol. 2014 Sep 19. 3. GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease, Seonmi Jo, Oleg Yarishkin, Yu Jin Hwang, Ye Eun Chun, Mijeong Park, Dong Ho Woo, Jin Young Bae, Taekeun Kim, Jaekwang Lee, Heejung Chun, Hyun Jung Park, Da Yong Lee, Jinpyo Hong, Hye Yun Kim, Soo-Jin Oh, Seung Ju Park, Hyo Lee, Bo-Eun Yoon, YoungSoo Kim, Yong Jeong, Insop Shim, Yong Chul Bae, Jeiwon Cho, Neil W Kowall, Hoon Ryu, Eunmi Hwang, Daesoo Kim & C Justin Lee Nat Med. 2014 Jun 29. 4. AU-rich element-binding protein negatively regulates CCAAT enhancer-binding protein mRNA stability during long-term synaptic plasticity in Aplysia. Lee YS, Choi SL, Jun H, Yim SJ, Lee JA, Kim HF, Lee SH, Shim J, Lee K, Jang DJ, Kaang BK. Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15520-5. Epub 2012 Sep 4. 5. PKA-activated ApAF-ApC/EBP heterodimer is a key downstream effector of ApCREB and is necessary and sufficient for the consolidation of long-term facilitation. Lee JA, Lee SH, Lee C, Chang DJ, Lee Y, Kim H, Cheang YH, Ko HG, Lee YS, Jun H, Bartsch D, Kandel ER, Kaang BK. J Cell Biol. 2006 Sep 11;174(6):827-38. 6. Regulation of ApC/EBP mRNA by the Aplysia AU-rich element-binding protein, ApELAV, and its effects on 5-hydroxytryptamine-induced long-term facilitation. Yim SJ, Lee YS, Lee JA, Chang DJ, Han JH, Kim H, Park H, Jun H, Kim VN, Kaang BK. J Neurochem. 2006 Jul;98(2):420-9. 7. SALM synaptic cell adhesion-like molecules regulate the differentiation of excitatory synapses.Ko J, Kim S, Chung HS, Kim K, Han K, Kim H, Jun H, Kaang BK, Kim E. Neuron. 2006 Apr 20;50(2):233-45.

  • Min-ho Nam
  • Research fellow
  • MD (Korean Medicine), PhD from Kyung Hee University
  • dr.namminhogmail.com

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  • Education

    2013.03 – 2017. 02 Ph.D. from College of Korean Medicine, Kyung Hee University 
    Advisor: Kwang Seok Ahn, Bum Sang Shim 
    Mentor: Justin C. Lee (Korea Institute of Science and Technology) 
    Honors: 1st prize of oral presentation at annual workshop of Brain Science Institute, KIST (2014), Poster award at 2015 Glia Meeting Korea (2015), Poster award at Brain conference 2015 (2015), 2nd prize of oral presentation at KIST Junior R&D Expo (2016), Poster award at 2017 Glia Meeting Korea (2017)

    2011.03 – 2013.02 M.S. from College of Korean Medicine, Kyung Hee University 
    Advisors: Kwang Seok Ahn, Seung-Hoon Choi 
    Mentor: Kwang-Sup Soh (Seoul National University) 
    Thesis: Investigation of the primo vascular system underneath the superior sagittal sinus in the brain 
    Honors: Korea Junior Research Fellowship (2012~2015)

    2004.03 - 2011.02 MD (Korean Medicine) and B.S. from College of Korean Medicine, Kyung Hee University 
    Honors: Youth Heojun Award (2010), Korea Presidential Youth Talent Award (2010), Dean's honored graduate (2011)

    2001.03 - 2004.02 Korean Minjok Leadership Academy (민족사관고등학교)


    Experience 
    Center for glia-neuron interaction, Brain Science Institute, Korea Institute of Science and Technology 
    Post-doc, 2017.03 – present

    Lab for glia-neuron interaction, Center for Neural Science and Center for Functional Connectomics Center, Korea Institute of Science and Technology 
    Visiting graduate student, 2013.03 – 2017.02

    Nano Primo Research Center, Advanced Institute of Convergence Technology, Seoul National University 
    Visiting graduate student, 2011.03 – 2013.02

    Department of Pathology, College of Korean Medicine, Kyung Hee University 
    Research assistant, 2011.03 - 2012.03

    Biomedical Physics Laboratory, College of Physics & Astronomy, Seoul National University 
    Researcher, 2011.01 - 2011.02


    Publications – papers

    Lee SW*, Nam MH*, Lee BC, Herbal Acupuncture for Type 2 Diabetes: A Systematic Review, Experimental and Therapeutic Mededicine, 2017, accepted

    Nam MH, Jung SJ, Lim J, Seo E, Lim J, Lee SJ, Yoon SZ, Soh KS, A novel fibrous duct structure in the brain meninges discovered using polarized light microscopy, Journal of Korean Physical Studies, 2016;68(10):1246-53.

    Nam MH*, Lee SW*, Na HY, Yoo JH, Paik SH, Ahn KS, Ahn YM, Ahn SY, Choi SH, Lee BC, Herbal Acupuncture for the Treatment of Obesity, Journal of Acupuncture & Meridian Studies, 2016, 9(2):49-57.

    Kim J, Stefanov M, Nam MH, Kim S, Tracing Mercox Injected at Acupuncture Points under the Protocol of Partial Body Macerations in Mice, Journal of Acupuncture & Meridian Studies, 2015;8(6):314-20.

    Nam MH, Ahn KS, Choi SH. Acupuncture: A potent tool for inducing adult neurogenesis, Neural Regeneration Research, 2015;10(1):33-35.

    Nam MH*, Baek M*, Lim J, Lee S, Yoon J, Kim J, Lee MS, Soh KS. Discovery of a novel fibrous tissue in the spinal pia mater by polarized light microscopy, Connective Tissue Research, 2014;55(2):147–155.

    M. Stefanov, M. Potroz, J. Kim, J Lim, Richard Cha, MH Nam. The Primo Vascular System as a New Anatomical System, Journal of Acupuncture & Meridian Studies, 2013;6(6):331-338.

    SJ Jung, KH Bae, MH Nam, HM Kwon, YK Song, KS Soh, Primo Vascular System Floating in Lymph Ducts of Rats, Journal of Acupuncture & Meridian Studies, 2013;6(6):306-318. (Featured article)

    Nam MH, Ahn KS, Choi SH. Acupuncture stimulation induces neurogenesis in adult brain, International Review of Neurobiology, 2013;111:67-90.

    Lee SH, Bae KH, Kim GO, Nam MH, Choi YB, Kwon HM, Ryu Y, Soh KS. Primo vascular system in the lymph vessel from the inguinal to the axillary nodes, Evidence-Based Complementary and Alternative Medicine, vol. 2013, Article ID 472704, 6 pages, 2013. doi:10.1155/2013/472704.

    Bae KH, Park SH, Lee BC, Nam MH, Yoon JW, Kwon HM, Yoon SZ. Novel threadlike structures may be present on the large animal organ surface: evidence in swine model, Evidence-Based Complementary and Alternative Medicine, vol. 2013, Article ID 758763, 5 pages, 2013. doi:10.1155/2013/758763.

    Stefanov M, Kim JD, Nam MH, Soh KS. New approach of corrosion casting using direct injection of mercox into the parenchyma of different organs, The Anatomical Record, 2013;296:724–725.

    Nam MH, Lim J, Choi SH, Kim SC, Soh KS. A primo vascular system underneath the superior sagittal sinus in the brain of a rabbit, Journal of Acupuncture & Meridian Studies, 2012;5(5):210-217.

    Nam MH, Choi SH, Soh KS. Light and primo vascular system in the brain, Journal of the Korean Physical Society, 2012;60(6):903-906.

    Nam MH, Yin CS, Choi SH, Soh KS. Adult neurogenesis and acupuncture stimulation at ST36, Journal of Acupuncture & Meridian Studies, 2011;4(3):153-158.

    Nam MH, Kim Y, Kim H, Park J, Yeh HY, Lee YS, Lee S, Jung WM, Hong YK, Lee H, Park HJ, Chae Y, A Comparison Study of Factors of Willingness to Use Traditional Medicine between Korean, Chinese and Taiwanese, J Korean Oriental Med 2011;32(1):36-55.

    Kim SY, Kim H, Nam MH, Li Y, Chung HC, Park HJ, Lee H, Chae Y, Evaluation of a Traditional Korean Medicine Content Factor and Satisfaction with the Drama ‘Daejanggeum’, The Journal of Korean Acupuncture & Moxibustion Society, 2010;27(1):11-20.

  • Youngeun Han
  • Ph.D course (UST)
  • Astrocytic volume regulation, Glia-Neuron interaction
  • hye0926ibs.re.kr

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  • EDUCATION Undergraduate 2006/3~2010/8 Dongguk University, Seoul, Korea Department of Life Science Graduate 2010/8~Present KIST(Korea Institute of Science and Technology) Ph.D course in Neroscience program (UST) Thesis advisor : Dr. C.Justin Lee RESEARCH INTERESTS Astrocytic volume regulation, Glia-Neuron interation RESEARCH EXPERIENCES Graduate Research Assist. 2010/8~Present Justin Lee’s Lab. KIST PUBLICATIONS POSTER PRESENTATION

     

  • Wuhyun Koh
  • Postdoc
  • Synaptic plasticity and cognitive flexibility, gliotransmitter releases
  • whvankohibs.re.kr

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  • Wuhyun Koh

    Birth Date : November 12, 1989

    Citizenship : Republic of Korea

    Tel : +82-10-6361-2748

    Email : whvankoh@gmail.com (general) or whvankoh@ibs.re.kr (institute)

    Current Title : Ph. D. course

     

    EDUCATION

    2008.03 ~ 2012.08

    B.A. in Korea University, Republic of Korea

    2013.08 ~ 2018.11

    Researcher, Center for Functional Connectomics, Korea Institute of Science and Technology (KIST), Republic of Korea

    2013.08 ~ present

    Integrated Ph.D. course, in University of Science and Technology (UST), Republic of Korea

    2018.02 ~ present

    Technical Research Personnel (Mandatory military service in Republic of Korea)

    2018.12 ~ present

    Researcher, Center for Cognition and Sociality, Institute for Basic Science (IBS), Republic of Korea

     

    RESEARCH INTERESTS

    Astrocyte-Neuron Interaction, Reversal Learning

     

    PUBLICATIONS

    S.-J. Oh, J. Lee, H.-B. Kim, J. Lee, S. Han, J. Bae, G.-S. Hong, W. Koh, J. Kwon, E.-S. Hwang, D. Woo, I. Youn, I.-J. Cho, Y. Bae, S. Lee, J. Shim, J.-H. Park, J. C. Lee, Ultrasonic Neuromodulation via Astrocytic TRPA1. Current Biology 29, 3386-797583616 (2019)10.1016/j.cub.2019.08.021).

    M.-H. Nam, K.-S. Han, J. Lee, W. Won, W. Koh, J. Bae, J. Woo, J. Kim, E. Kwong, T.-Y. Choi, H. Chun, S. Lee, S.-B. Kim, K. Park, S.-Y. Choi, Y. Bae, J. C. Lee, Activation of Astrocytic μ-Opioid Receptor Causes Conditioned Place Preference. Cell Reports 28, 1154-116600000 (2019)10.1016/j.celrep.2019.06.071).

    J. Woo, Y.-E. Han, W. Koh, J. Won, M. Park, H. An, J. C. Lee, Pharmacological Dissection of Intrinsic Optical Signal Reveals a Functional Coupling between Synaptic Activity and Astrocytic Volume Transient. Experimental Neurobiology 28, 30-42 (2019)10.5607/en.2019.28.1.30).

    W. Koh, Y. Park, S. Lee, J. C. Lee, AAV-Mediated Astrocyte-Specific Gene Expression under Human ALDH1L1 Promoter in Mouse Thalamus. Experimental Neurobiology 26, 350-361 (2017)10.5607/en.2017.26.6.350).

    H. Park, K.-S. Han, J. Seo, J. Lee, S. M. Dravid, J. Woo, H. Chun, S. Cho, J. Bae, H. An, W. Koh, B.-E. Yoon, R. Berlinguer-Palmini, G. Mannaioni, S. F. Traynelis, Y. Bae, S.-Y. Choi, J. C. Lee, Channel-mediated astrocytic glutamate modulates hippocampal synaptic plasticity by activating postsynaptic NMDA receptors. Molecular Brain 8, 1-16 (2015)10.1186/s13041-015-0097-y).

     

    EXPERIENCES

    2009. 06 ~ 2009. 08 48th National Undergraduate Symposium on Biology (NUSB),
    Topic : Mitochondia

    2010. 06 ~ 2010. 08 49th National Undergraduate Symposium on Biology (NUSB),
    Topic : Epigenetics

    2010. 06 ~ 2011. 03 Undergraduate Internship Program in Lab of Neuroscience (Dr. Bongjune Yoon), Korea University, Republic of Korea

    2011. 06 SURF (Summer Undergraduate Research Fellowship) program in Molecular Neuroscience Lab (Dr. JungHoon Kim), POSTECH, Republic of Korea

    2011. 02 ~ 2011. 08 50th National Undergraduate Symposium on Biology (NUSB) Staff,
    Topic : Neuroscience

    2012. 06 ~ 2012. 08 51st National Undergraduate Symposium on Biology (NUSB),
    Topic : Bioinformatics

    2013. 04 ~ 2013. 08 Undergraduate Internship Program in Glia-Neuron Interaction Lab
    (Dr. C. Justin Lee), KIST, Republic of Korea

     

    AWARDS

    1st prize for “Best oral presentation” at the 2018 Brain Science Institute (BSI) annual meeting held in

    Pyeongchang, Republic of Korea

  • Joungha Won
  • Postdoc
  • jwonibs.re.kr

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  •  

    Personal Record

     

    Name                                       : Joungha Won

    Country of Citizenship            : Republic of Korea

    Current Status                     : Post-Doctoral fellow, Center for Cognition and Sociality, Institute for Basic Science (IBS)

    E-mail                                      : jwon@ibs.re.kr

     

     

    Education

     

    2007. 03 ~ 2013. 02               BS, Department of Biology, Kyung Hee University

    2013. 03 ~ 2021. 02               Integrated MS/Ph.D, program, Department of Biological Science, KAIST

     

     

    Academic Appointments

     

    2013. 02 ~                                Ph.D. Candidate, Bio-Imaging and Optogenetics Laboratory, KAIST 
                     (Professor Won Do Heo’s Lab)

    2015. 03 ~ 2018. 10                Student Researcher, Center for Neuroscience,

    Center for Glia-Neuron interaction, KIST (C. Justin Lee’s Lab)

    2018.11 ~                                Student Researcher, Center for Cognition and Sociality,

                                                    Cognitive Glioscience Group, IBS (C. Justin Lee’s lab)

     

    Thesis title

    Development of optogenetic molecular probe for inhibition of synaptic transmission, and detection protocol for the COVID-19

     

     

     

    Research Interests

     

    Activity-dependent astrocytic proBDNF release in Learning and Memory

    Activity-dependent and environment-dependent BDNF expression in astrocyte.

    Development an optogenetic trap for reversible inhibition of vesicular release, synaptic transmission and behavior

    Investigate calcium activity and its functions in astrocyte.

    The function of astrocytic molecule in pathophysiological status, especially in stroke and Parkinson's disease.

    Diagnostic tool development.

     

     

    Experimental Techniques

     

    Imaging experiment: Confocal imaging, Live-cell imaging, Intrinsic optical signaling imaging, Super-resolution imaging, Calcium imaging, Total internal reflection fluorescence imaging, multi-photon image, etc.

    Electrophysiology: whole-cell patch clamp in acute brain tissue and cultured cell, and field recording

    Molecular biology: SNP analysis, cloning, qRT-PCR, diagnosis tool development, etc.

    Next-Generation Sequencing (NGS)

    Primary culture: primary cortical, hippocampal and spinal cord astrocyte cell culture, cortical neuron culture

    Animal behavior experiment: Fear conditioning, Open field test, Novel object/place recognition test, Passive avoidance test, etc.

    Histology: Immunohistochemistry, Immunocytochemistry

    Optogenetics experiment: Imaging, molecular biology, and behavior experiment with optogenetic tools.

     

     

    Awards

     

    Best presentation Award, The Korean Society for Brain and Neural Sciences, 2020

    Best article award of The Korean Society for Brain and Neural Sciences, The Korean Society for Brain and Neural Sciences, 2021

    Best presentation Award, The Korean Society for Brain and Neural Sciences, 2021

     

     

     

    Publications

     

    Published

    1. Joungha Won, Lee S, Park M, Kim TY, Park GM, Choi BY, Kim D, H Chnag, Heo WD, Kim V. N and Lee CJ., Development of a Laboratory-safe and Low-cost Detection Protocol for SARS-CoV-2 of the Coronavirus Disease 2019 (COVID-19)., Experimental Neurobiology Exp Neurobiol. 2020 Apr;29(2), 11 March (2020)

    2. Joungha Won, Hasan Hüseyin Kazan, Jea Kwon, Myungsun Park, Mehmet Ali Ergun, Sureyya Ozcan, Byung Yoon Choi, Won Do Heo* and C. Justin Lee*, Ultimate COVID-19 Detection Protocol Based on Saliva Sampling and qRT-PCR with Risk Probability Assessment, Experimental Neurobiology Exp Neurobiol. 2021 Feb 28; 30(1): 13–31.

    3. Chang KY, Woo D, Jung H, Lee S, Kim S, Won Joungha, Kyung T, Park H, Kim N, Yang HW, Park JY, Hwang EM, Kim D, Heo WD., Light-inducible receptor tyrosine kinases that regulate neurotrophin signalling., Nature Communications. 2014 Jun 4;5:4057. doi: 10.1038/ncomms5057.

    4. Kwon J, An H, Sa M, Joungha Won, Shin JI, Lee CJ., Orai1 and Orai3 in Combination with Stim1 Mediate the Majority of Store-operated Calcium Entry in Astrocyte., Exp Neurobiol 2017 Feb;26(1):42-54. (2017)

    5. Woo DH, Bae JY, Nam MH, An H, Ju YH, Joungha Won, Choi JH, Hwang EM, Han KS, Bae YC, Lee CJ, Activation of Astrocytic μ-opioid Receptor Elicits Fast Glutamate Release Through TREK-1-Containing K2P Channel in Hippocampal Astrocytes., Front Cell Neurosci. 2018 Sep 27;12:319. (2018)

    6. Woo J, Han YE, Koh W, Joungha Won, Park MG, An H, Lee CJ., Pharmacological Dissection of Intrinsic Optical Signal Reveals a Functional Coupling between Synaptic Activity and Astrocytic Volume Transient., Exp Neurobiol. 2019 Feb;28(1):30-42 (2019)

    7. Han YE, Kwon J, Joungha Won, An H, Jang MW, Woo J, Lee JS, Park MG, Yoon BE, Lee SE, Hwang EM, Jung JY, Park H, Oh SJ, Lee CJ., Tweety-homolog (Ttyh) Family Encodes the Pore-forming Subunits of the Swelling-dependent Volume-regulated Anion Channel (VRACswell) in the Brain., Exp Neurobiol. 2019 Apr;28(2):183-215 (2019)

    8. Park M, Joungha Won, Chio BY, Lee CJ., Optimization of primer sets and detection protocols for SARS-CoV-2 of coronavirus disease 2019 (COVID-19) using PCR and real-time PCR., Experimental & Molecular Medicine 52, pages963–977(2020)

    9. Kim TY, Jeon S, Jang Y, Gotina Lizaveta, Joungha Won, Ju YH, Kim S, Jang MW, Won W, Park MG, Pae AN, Han S, Kim S, Lee CJ, Platycodin D, a natural component of Platycodon grandiflorum, prevents both lysosome-and TMPRSS2-driven SARS-CoV-2 infection by hindering membrane fusion, Experimental & Molecular Medicine, 2021

     

    Under Review/Accepted article (on 7th, Jan., 2021)

    1. Joungha Won, Pankratov Y, Lee S, Kim A, Jang MW, Lee CJ*., Heo WD*., Opto-vTrap, an optogenetic trap for reversible inhibition of vesicular release, synaptic transmission and behavior., Neuron, Under review

  • Soo-Jin Oh
  • Senior Researcher
  • Ph.D.: School of Dentistry, SNU
  • osjkist.re.kr

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  • 1. EDUCATION:

    - B.S. 2002/2 Biotechnology

    Department of Biotechnology, Yonsei University, Seoul, Korea

     

    - M.S. 2004/2 Microbialgenetics

    School of Biological Sciences, SeoulNationalUniversity,Seoul,Korea

    Dissertation Title: “Genetic Engineering to Improve the Zymomonas mobilis ZM4”

    Advisor: Hyen Sam Kang, Ph.D.

     

    - Ph.D. 2014/2 Neuroscience

    Department of Craniomaxillofacial Cell and Developmental Biology

    School of Dentistry,SeoulNationalUniversity,Seoul,Korea

    Dissertation Title: “Expression, Function and Regulation of Bestrophin-1 Channel in Astrocyte”

    Advisor: Seungbok Lee, Ph.D. and C. Justin Lee, Ph.D.

     

    2. RESEARCH EXPERIENCE:

     

    Jun. 2000 ~ Feb. 2001 Research assistant in Biochemistry and virus laboratory (Advisor: Baik-Lin Seong, Ph.D. professor in Yonsei University)

    Sep. 2002 ~ Jun. 2003 Teaching assistant in School of Biological Sciences, Seoul National University

    Jan. 2004 ~ Mar. 2005 Research Scientist in Biomedical Center, KIST (Korea Institute of Science and Technology. Advisor: Yeon Gyu Yu, Ph.D. Principal Research Scientist in KIST)

    Apr. 2005 ~ Feb. 2016 Research Scientist in Center for Neuroscience, KIST (Korea Institute of Science and Technology. Advisor: C. Justin Lee, Ph.D. Principal Research Scientist in KIST)

    Jun. 2012 ~ Jul. 2012 Visiting researcher in The Marine Biological Laboratory (MBL) in Woods Hole

    Mar. 2016 ~ Present Senior Research Scientist in Convergence Research Center for Diagnosis, Treatment and Care System of Dementia and Center for Glia-Neuron interaction, KIST (Korea Institute of Science and Technology)

     

    3. PUBLICATIONS :

     

    1. Jeong-Sun Seo, Hyonyong Chong, Hyun Seok Park, Kyoung-Oh Yoon, Cholhee Jung, Jae Joon Kim, Jin Han Hong, Hyungtae Kim, Jeong-Hyun Kim, Joon-Il Kil, Cheol Ju Park, Hyun-Myung Oh, Jung-Soon Lee, Su-Jung Jin, Hye-Won Um, Hee-Jong Lee, Soo-JinOh, Jae Young Kim, Hyung Lyun Kang, Se Yong Lee, Kye Joon Lee and Hyen Sam Kang. “The genome sequence of the ethanologenic bacterium Zymomonas mobilis ZM4” Nature Biotechnology (2004) 23: 63-68

    2. Soo-JinOh, JungHwanPark,SungyuHan,JaeKyunLee,EunJooRohandCJustinLee.“DevelopmentofselectiveblockersforCa2+-activatedCl-channelusingXenopus laevis oocytes with an improved drug screening strategy” Molecular Brain (2008) 1: 14-24 [first author]

    3. Yun-Kyoung Kim, Soo-JinOh, Bong-Suk Jin, ChanhooPark,HyesungJeon,DooWanBoo,andYeonGyuYu.“Acell-basedmethodtomonitortheinteractionbetweenhepatitisBviruscapsidandsurfaceproteins”Bulletin of the Korean Chemical Society (2009) 30: 577-581

    4. Mihye Lee, Sang Kyoo Paik, Min-Jung Lee, Yoon-Jung Kim, Sungdae Kim, Minyeop Nahm, Soo-JinOh, Hyun-Man Kim, Jeongbin Yim, C. Justin Lee, Yong Chul Bae and Seungbok Lee. “Drosophila atlastin regulates the stability of muscle microtubules and is required for synapse development” Developmental Biology (2009) 330: 250-262

    5. HyungjuPark*,Soo-JinOh*, Kyung-Seok Han, Dong Ho Woo, HyekyungPark,GuidoMannaioni,StephenF.Traynelis,andC.JustinLee.“Bestrophin-1encodesfortheCa2+-activatedanionchannelinhippocampalastrocytes” The Journal of Neuroscience (2009) 29: 13063-13073 [*co-first authors]

    6. Soojung Lee, Bo-Eun Yoon, Ken Berglund, Soo-JinOh, HyungjuPark,Hee-SupShin,GeorgeJ.Augustine,C.JustinLee.“Channel-mediatedtonicGABAreleasefromglia”Science (2010) 330: 790-796

    7. Rae Hyung Ryu, Soo-JinOh, Ra Mi Lee, Seong Won Jeong, Lily Yeh Jan, Chi Ho Lee, C. Justin Lee, Sang Min Jeong. “Cloning and heterologous expression of new xANO2 from Xenopus laevis” Biochemical and Biophysical Research Communications (2011) 408: 559-565

    8. Ra Mi Lee, Rae Hyung Ryu, Seong Won Jeong, Soo-JinOh, Hue Huang, Jin Soo Han, Chi Ho Lee, C. Justin Lee, Lily Yeh Jan, and Sang Min Jeong. “Isolation and Expression Profile of the Ca2+-ActivatedChlorideChannel-likeMembraneProtein6GeneinXenopus laevis” Laboratory Animal Research (2011) 27: 109-116

    9. Dong Ho Woo, Kyung-Seok Han, Jae Wan Shim, Bo-Eun Yoon, Eunju Kim, Jin Young Bae, Soo-JinOh, Eun Mi Hwang, Alan D. Marmorstein, Yong Chul Bae, Jae-Yong Park, and C. Justin Lee. “TREK-1 and Best1 Channels Mediate Fast and Slow Glutamate Release in Astrocytes upon GPCR Activation” Cell (2012) 151(1): 25-40

    10. Soo-Jin Oh, Kyung-Seok Han, Hyungju Park, Dong Ho Woo, Hye Yun Kim, Stephen F. Traynelis, and C Justin Lee. “Protease Activated Receptor 1-induced glutamate release in cultured astrocytes is mediated by Bestrophin-1 channel but not by vesicular exocytosis” Molecular Brain (2012) 5:38 [first author]

    11. Soo-JinOh, Seok Jin Hwang, Jonghoon Jung, Kuai Yu, Jeongyeon Kim, Jung Yoon Choi, H.Criss Hartzell, Eun Joo Roh, and C. Justin Lee. “MONNA, a Potent and Selective Blocker for Transmembrane Protein with Unknown Function 16/Anoctamin-1” Molecular Pharmacology (2013) 84:726-735 [first author]

    12. Hyungju Park, Kyung-Seok Han, Soo-JinOh, Seonmi Jo, Junsung Woo, Bo-Eun Yoon, and C. Justin Lee. “High glutamate permeability and distal localization of Best1 channel in CA1 hippocampal astrocyte” Molecular Brain (2013) 6:54

    13. Seonmi Jo, Oleg Yarishkin, Yu Jin Hwang, Ye Eun Chun, Mijeong Park, Dong Ho Woo, Jin Young Bae, Taekeun Kim, Jaekwang Lee, Heejung Chun, Hyun Jung Park, Da Yong Lee, Jinpyo Hong, Hye Yun Kim, Soo-JinOh, Seung Ju Park, Hyo Lee, Bo-Eun Yoon, YoungSoo Kim, Yong Jeong, Insop Shim, Yong Chul Bae, Jeiwon Cho, Neil W Kowall, Hoon Ryu, Eunmi Hwang, Daesoo Kim and C Justin Lee. “GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease” Nature Medicine (2014) doi:10.1038/nm.3639

    14. Seung Eun Lee, Jaekwang Lee, Charles Latchoumane, Boyoung Lee, Soo-JinOh, Zahangir Alam Saud, Cheongdahm Park, Ning Sun, Eunji Cheong, Chien-Chang Chen, Eui-Ju Choi, C. Justin Lee, and Hee-Sup Shin. “Rebound burst firing in the reticular thalamus is not essential for pharmacological absence seizures in mice” PNAS (2014) 111(32): 11828-11833

    15. Bo-Eun Yoon, Junsung Woo, Ye-Eun Chun, Heejung Chun, Seonmi Jo, Jin Young Bae, Heeyoung An, Joo Ok Min, Soo-JinOh, Kyung-Seok Han, Hye Yun Kim, Taekeun Kim, Young Soo Kim, Young Chul Bae, and C. Justin Lee. “Glial GABA, synthesized by monoamine oxidase B, mediates tonic inhibition” The Journal of Physiology (2014) Sep 19

    4. PATENTS :

    1. Use of anthranillic acid derivatives on calcium activated chloride channel (#10-0892591 02-Apr-2009)

    2. Cellular imaging of the interaction between HBV capsid and surface proteins, and its application for screening of inhibitory ag (#10-0949310 17-Mar-2010)

    3. Method for screening a glutamate release inhibitor in an astrocyte (#8,871,463 28-Oct-2014, # 10-1418061 3-Jul-2014)

    4. Novel compounds as chloride channel blocking agent (#10-1464280 17-Nov-2014)

     

     

    5. AWARDS and HONORS :

     

    Brain Korea 21 (BK21) Scholarship (2002 - 2003)

    KIST우수연구개발팀상 (2011)

    Poster award in 2014 BSI symposium in Korea

    Poster award in 2016 The Glia Section of the Korea Society of Brain and Neural Science

    Travel award in Japan Neuroscience Society 2016

     

     

    6. POSTER Presentation :

     

    1. The 12th Japan-Korea Joint symposium on Drug Design and Development Jun-2008

    Title: Synthesis and biological activities of anthranilic acid derivatives as Ca2+activatedCl-channelblockers

    2. International Society for Neurochemistry Aug-2009

    Title: Bestrophin-1 Encodes for the Ca2+ActivatedAnionChannelinhippocampalastrocytes

    3. Society For Neuroscience Nov-2010

    Title: Astrocytic Ca2+-activatedanionchannel,Bestrophin-1,ispermeabletoglutamateandGABA

    4. Society For Neuroscience Nov-2013

    Title: MONNA, a potent and selective blocker for TMEM16A/Anoctamin-1

    5. The Glia Section of the Korea Society of Brain and Neural Science

    Title: Ultrasonic brain stimulation modulates neuronal activity via mechano-sensitive TRPA1 channels in astrocytes Jan-2016

  • Yeonha Ju
  • Ph.D course (UST)
  • Neuron-glia interaction, Reactive astrocyte
  • yeonha92ibs.re.kr

Detail

  • Information
  • Education

    March 2011 – February 2015, Konkuk University, Major: Life science

    March 2015 – Present, University of Science & Technology (UST) in Korea, Major: Neuroscience

     

    Work experience

    February 2014 – March 2014, Internship program in Korean basic science institute (KBSI), study for two photon microscope confocal microscope with IHC

    March 2014 – February 2015, Internship in Korea Institute of science and technology (KIST)

     

    Experienced research skills

    Slice Patch, Immunohistochemistry, Confocal imaging, Behavior test (Passive avoidance test, forced swimming test, Rotarod test), Molecular biological techniques (Cloning, Subcloning and RT-PCR, shRNA making), Stereotaxic Surgery, Cell culture (Primary astrocyte, Primary neuron, cell lines)

     

    Publication

    Dong Ho Woo,† Jin Young Bae,† Min-Ho Nam,† Heeyoung An, Yeon Ha Ju, Joungha Won, Jae Hyouk Choi, Eun Mi Hwang, Kyung-Seok Han, Yong Chul Bae, and C. Justin Lee (2018). "Activation of Astrocytic mu-opioid Receptor Elicits Fast Glutamate Release Through TREK-1-Containing K2P Channel in Hippocampal Astrocytes." Frontiers in Cellular Neuroscience 12.

    Jong-Hyun Park, Yeon Ha Ju, Ji Won Choi, Hyo Jung Song, Bo Ko Jang, Junsung Woo, Heejung Chun, Hyeon Jeong Kim, Su Jeong Shin, Oleg Yarishkin, Seonmi Jo, Mijeong Park, Seul Ki Yeon, Siwon Kim, Jeongyeon Kim, Min-Ho Nam, Ashwini M. Londhe, Jina Kim, Sung Jin Cho, Suengmok Cho, Changho Lee, Sung Yeoun Hwang, Sang Wook Kim, Soo-Jin Oh, Jeiwon Cho, Ae Nim Pae, C. Justin Lee, Ki Duk Park (2019). “Newly developed reversible MAO-B inhibitor circumvents the shortcomings of irreversible inhibitors in Alzheimer’s disease.” Science Advance 5.

     

    Awards

    Oral presentation in KIST - BSI conference (Sep, 2017) _New reversible MAO-B inhibitor KDS2010 abolishes astrogliosis and memory impairment in Alzheimer’s disease model

    Poster presentation at Korea Society of Neurodegeneration Disorder (KSND) (Mar, 2018) _ PyrPeg, a Novel Two-photon Probe to Selectively Detect Aβ in Alzheimer’s Disease

     

     

  • Jeong Im Shin
  • Ph.D course (UST)
  • sjllisibs.re.kr

Detail

  • Information
  • undergraduate : 2009.03~2016.02 Korea University

  • Junsung Woo
  • Research fellow

  • Junghwa Shin
  • Lab manager
  • jh.shinkbri.re.kr

  • Jeongyeon Kim
  • Research fellow
  • jykimkbri.re.kr

  • Jaekwang Lee
  • Research fellow
  • jkleekfri.re.kr

  • Junyoung Heo
  • Visiting Scientist (M.D)
  • junyoung3cnu.ac.kr

Detail

  • Information
  • Visiting Scientist (M.D)
    Contact : junyoung3@cnu.ac.kr
    From 2011.09 to 2012. 09
    Currently at Chung-nam National University
    Department of Biochemistry, College of Medicine
    Assistant professor
  • Elliot Kwong
  • Research Assistant
  • elliotkwonggmail.com

Detail

  • Information
  • Research Assistant
    Research interset : glia-neuron interaction
    from 2012.3 to 2014.2
    elliotkwong@gmail.com
  • Kyung-Seok Han
  • Postdoctoral fellow
  • neuron711gmail.com

Detail

  • Information
  • Postdoctoral fellow
    neuron711@gmail.com
    from 2011.6 to 2014.3
    Massachusetts Institute of Technology
    The Picower Institute for Learning and Memory
    Department of Brain and Cognitive Sciences
    Currently at MIT (Post-Doc)
  • Jinpyo Hong
  • Research Professor
  • biohjpgmail.com

Detail

  • Information
  • Research Professor
    from 2011.8 to 2014. 3
    biohjp@gmail.com
    Currently at Chung-nam National University
  • Seonmi Jo
  • Postdoctoral fellow
  • joseonmigmail.com

Detail

  • Information
  • postdoctoral fellow
    KAIST
    joseonmi@gmail.com
  • Sea Hyung Park
  • Intern - Post Bachelor

Detail

  • Information
  • Intern - Post Bachelor
    from 2013. 9 to 2014. 8
    Currently at KAIST
  • Ye eun Chun
  • Ph.D course (UST)

  • Dong-ho Woo
  • Postdoctoral fellow
  • donghowoo24gmail.com

Detail

  • Information
  • Postdoctoral fellow
    donghowoo24@gmail.com
    from 2005 to 2013
    National Institutes of Health (NIH)
    Eunice Kennedy Shriver National Institute of Child Health and Human Developmen
    Currently at KIT
  • Bo-Eun Yoon
  • Assistant Professor, Ph.D.
  • boeunyoongmail.com

Detail

  • Information
  • Assistant Professor, Ph.D.
    Currently at Dankook University
    From 2006.07 to 2012.08
    boeunyoon@gmail.com
  • Jisoo Kim
  • Lab manager

  • Seungju Park
  • Ph.D course
  • gom0303hanmail.net

Detail

  • Information
  • Ph.D course
    Research interest: reactive astrocyte
    Technique: molecular biology, immunohistochemistry
    from 2012.4 to 2012.12
    gom0303@hanmail.net
    Currently at KAIST
  • Hyungju Park
  • Postdoc
  • mythherogmail.com

Detail

  • Information
  • Postdoc.
    From 2007.9 to 2009.7
    UC Berkeley, Moo-ming Poo's lab.
    Contact : mythhero@gmail.com
    Currently at KBRI (선임연구원)
  • Jaeyoung Kim
  • Researcher
  • jaydawgsgmail.com

Detail

  • Information
  • Researcher
    From 2010.12 to 2011. 7
    Johns Hopkins University
    jaydawgs@gmail.com
  • Taekeun Kim
  • Research Assistant
  • monsterktkgmail.com

Detail

  • Information
  • Research Assistant
    monsterktk@gmail.com
    From 2011.04 to 2012.08
    Currently at Max Planck Florida Institute
    Currently at MIT (Ph.D. Course)
  • Soon-Young Jung
  • Ph.D course (UST)
  • The role of estrogen in tonic inhibition
  • syjjeonghanmail.net

Detail

  • Information
  • Education 2013.03 - now Integrative program, neuroscience University of Science and Technology, KIST 2004.03 - 2011.01 The integrated Master's & Ph.D. course, molecular & cell bi ology Graduate school of Life Sciences & Biotechnol gy, Korea University 1999.03 - 2004.02 B.S. in Life Sciences, Korea University Research Experiences 2012.05 - 2013.07 Dr. Mikyoung Park’s lab, Brain Science Institute , KIST 2004.03 - 2011.01 Dr. Young-Gyu Ko’s lab, Korea University Study of transcriptional regulation of TRIM72 expression during C 2C12 differentiation Development of two-photon dyes probing lipid rafts Research Skills Cell and slice patch clamp, Western blots, RT-PCR, Molecular cloning, Immunofluorescence, Lucifera se assay, Chromatin immunoprecipitation, EMSA, etc. Areas of Interest The role of estrogen in tonic inhibition Publications [1] S.Y. Jung*, and Y.G. Ko, TRIM72, a novel negative feedback regulato r of myogenesis, is transcriptionally activated by the synergism of MyoD (or myogenin) and MEF2. Biochem Biophys Res Commun 396 (2010) 238-45. [2] B.W. Kim, J.W. Lee, H.J. Choo, C.S. Lee, S.Y. Jung*, J.S. Yi, Y.M. Ham, J. H. Lee, J. Hong, M.J. Kang, S.G. Chi, S.W. Hyung, S.W. Lee, H.M. Kim, B.R. Cho, D.S. Min, G. Yoon, and Y.G. Ko, Mitochondrial oxidative phosphorylation system is recruited to detergent-resistant lipid rafts during myogenesis. Proteomics 10 (2010) 2498-515. [3] C.S. Lee, J.S. Yi, S.Y. Jung*, B.W. Kim, N.R. Lee, H.J. Choo, S.Y. Jang, J. Han, S.G. Chi, M. Park, J.H. Lee, and Y.G. Ko, TRIM72 negatively regulates myogenesis via targeting insulin receptor substrate-1. Cell Death Differ 17 (2009) 1254-65. [4] H.M. Kim, H.J. Choo, S.Y. Jung*, Y.G. Ko, W.H. Park, S.J. Jeon, C.H. Kim, T. Joo, and B.R. Cho, A two-photon fluorescent probe for lipid raft imaging: C-laurdan. Chembiochem 8 (2007) 553-9. [5] H.M. Kim, C. Jung, B.R. Kim, S.Y. Jung*, J.H. Hong, Y.G. Ko, K.J. Lee, and B.R. Cho, Environment-sensitive two-photon probe for intracellular free magnesium ions in live tissue. Angew Chem Int Ed Engl 46 (2007) 3460-3. [6] K.B. Kim, J.W. Lee, C.S. Lee, B.W. Kim, H.J. Choo, S.Y. Jung*, S.G. Chi, Y.S. Yoon, G. Yoon, and Y.G. Ko, Oxidation-reduction respiratory chains and ATP synthase complex are localized in detergent-resistant lipid rafts. Proteomics 6 (2006) 2444-53.

     

  • Eunyoung Han
  • Researcher
  • viruskist.re.kr

  • Clare Jung Yoon Choi
  • Undergraduate Research Assistant
  • jungchoiprinceton.edu

Detail

  • Information
  • Undergraduate Research Assistant
    jungchoi@princeton.edu
    From 2011.08 to 2012.05
    Currently at Princeton University
    Currently at Princeton (Ph.D. program)
  • Jonghoon Jung
  • Technical assistant

  • Hye-Won Shin
  • hwshin99yahoo.com

Detail

  • Information
  • Korea University, College of Medicine , Department of Anesthesiology and Pain Medicine, Professor
    hwshin99@yahoo.com
  • Yoonsik Kim
  • Ph.D. candidate
  • bluehawk75nate.com

Detail

  • Information
  • Ph.D. Candidate
    (from 2005.3 to 2009. 7)
    post doctoral fellow in
    Korea Univ. School of Medicine
    Contact : bluehawk75@nate.com
    Currently at UCLA (Post-Doc)
  • Myungsun Park
  • Researcher

Detail

  • Information
  • Contact details

    Name: Myung sun Park

    Date of birth and Place: February 19. 1994, Seoul, Korea

    Nationality: Republic of Korea

    Home address: 305, 118-28, Sinseong-dong, Yuseong-gu, Daejeon City, South Korea

    Tel) 82-10-8949-2583 e-mail) bak100000s@gmail.com

     

    Education and Training

    M.S., Hannam University, Daejeon, Republic of Korea, 2016-2018

    Department of Biological Science and Biotechnology

    B.S., Hannam University, Daejeon, Republic of Korea, 2012-2016

    Department of Biological Science and Biotechnology

     

    Dissertation Titles

    Abnormality of slow fiber in skeletal muscle of Huntington's disease mouse model (MS).

     

    Professional Experiences

    Researcher, Institute for Basic Science, Daegu, Republic of Korea, Daejeon, Republic of Korea, 2018-present

    Cognition and Sociality Center

    Researcher, Kyungpook National University, Daegu, Republic of Korea, 2018

    Medical Research Center

    Researcher, Korea Research Institute of Bioscience & Biotechnology (KRIBB), Daejeon, Republic of Korea, 2016-2018

    Aging Research Center

     

     Publications

     1. Park, M., Min, B., Jeon, K., Cho, S., Park, J. S., Kim, J., . . . Kang, Y. K. (2017). Age-associated chromatin relaxation is enhanced in Huntington's disease mice. Aging (Albany NY), 9(3), 803-822. doi:10.18632/aging.101193

     2. Min, B*., Park, M*., Jeon, K., Park, J. S., Seo, H., Jeong, S., & Kang, Y. K. (2018). Age-associated bimodal transcriptional drift reduces intergenic disparities in transcription. Aging (Albany NY), 10(4), 789-807. doi:10.18632/aging.101428, *co-first author.

     

    Research Presentations

    1. “Age-dependent reduction transcriptional disparities”, “Global hypomethylation on large retroelements in aged muscle” Spring Conference of the Korean Society for Gerontology, 2018, poster presentation

    2. "Age-associated chromatin relaxation is enhanced in Huntington's disease mice", KSMCB에피유전체학분과 심포지움, 2017, poster presentation

  • Bao-Wen Li
  • Research fellow
  • UNIST 103-417 (temporary office)

CV

  • Xu Zhang
  • Research fellow
  • UNIST 103-417 (temporary office)

CV

  • Han, Ah-reum
  • Senior Researcher
  • yaringongibs.re.kr

Detail

  • Information
  • Educations

    • ㆍ2009 B.S. Biotechnology, Korea University, Seoul, Korea.
    • ㆍ2017 Ph.D. Biosystems and Biotechnology, Korea University, Seoul, Korea.

     

    Careers

    • 2009-2017 Graduate Research Assistant, Korea University, Seoul, Korea.
    • 2013-2014 Visiting Researcher, Northwestern University, Evanston, IL ,USA.
    • 2017-2019 Postdoctoral Researcher,University of Pennsylvania, Philadelphia, PA, USA.

     

    Publications(first author)

    • Han Ah-reum, Kang HR, Son J, Kwon DH, Kim SH, Lee WC, Song HK, Song Mj, and Hwang KY. The structure of the pleiotropic transcription regulator CodY provides insight into its GTP-sending mechanism. Nucelic Acids Research, 44(19), 9483-9493(2016).
    • Han Ah-reum, Kim M-J, Kwan G-H, SOn J, Hwang KY, and Kim H-Y. Essential role fo the linker region in higher catalytic effeciency of a biofunctional methionine sulfoxide reductase AB Protein. Biochemistry, 55(36), 5117-5127(2016).
    • Han Ah-reum, Kim HS, Cho GY, Ki HS, Kim H-Y, Hwang KY. Crystallization and preliminary X-ray crystallographic analysis of the methionine sulfoxide reductase A domain of MsrAB from Haemophilus influenzae. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 68, 557-559(2012).
  • Fu, Yaoyao
  • Senior Researcher
  • fuyaoyaoibs.re.kr

Detail

  • Information
  • Educations

    • ㆍ2004 B.S. College of Bio&Food Technolgy, Dalian Institute of Light Industry, China.
    • ㆍ2007 M.S. College of Bio & Food Technology, Dalian Polytechnic University, China. 
    • ㆍ2010 Ph.D. College of Science, Yanbian University, China.

     

    Careers

    • 2010-2014 Department of Life Science, POSTECH, Korea.
    • 2014-2017 Postdoctoral Fellow, Synthetic Biology & Bioengineering Research Center, KRIBB, Korea.
    • 2017-2018 Associate professor,The Key Laboratory of Biotechnology for Medicinal Plant of Jiangsu Province, Jiangsu Normal University (JSNU), China.

     

    Publications(first/second author)

    • Yaoyao Fu, Soo-Jin Yeom, Kil Koang Kwon, Jungwon Hwang, Haseong Kim, Euijeon Woo, Dae-Hee Lee, and Seung-Goo Lee. Structural and functional analyses of the cellulase transcription regulator CelR. FEBS Lett. 2018 Aug; 592(16):2776-2785.
    • Yaoyao Fu, Youngran Kim, Kyeong Sik Jin, Hyun Sook Kim, Jong Hyun Kim, DongMing Wang, Minyoung Park, Chang Hwa Jo, Nam Hoon Kwon, Doyeun Kim, Myung Hee Kim, Young Ho Jeon, Kwang Yeon Hwang, Sunghoon Kim and Yunje Cho. Structure of the ArgRS-GlnRS- AIMP1 Complex and its implications for Mammalian Translation. Proc Natl Acad Sci U S A 2014 Oct 21;111(42):15084-9.
    • Yaoyao Fu, Hongshan Yu, Sihui Tang, Xiangchun Hu, Yuanhao Wang, Bing Liu, Chenxu Yu, Fengxie Jin. New dioscin-glycosidase hydrolyzing multi-glycosides of dioscin from Absidia strain. Journal of Microbiology and Biotechnology. 2010, 20(6): 1011-1017.
    • Yaoyao Fu, Hongshan Yu, Haimei Song, Xiaofeng Su, Mingchun Lu, Chunzhi Zhang, Fengxie Jin. Purification and characterization of new special saikosaponin-glycosidase. Chemical Journal of Chinese Universities. 2010, 31(6):1152-1157.
    • Yaoyao Fu, Bo Zhang, Xiaofeng Su, Hongshan Yu, Fengxie Jin. Production and properties of saikosaponin-glycosidase. Journal of Dalian Institute of Light Industry. 2007, 26(2): 136-139.
    • Yanan Wang, Yaoyao Fu, Fengxie Jin, Hongshan Yu. Separation and purification of diosgenin from fermentation. Journal of Dalian Polytechnic University. 2010, 29(1): 1-3.
    • Bo Yang, Yaoyao Fu, Shaoping Fu, Hongshan Yu, Fengxie Jin. Purification of ginsenoside Re from leaf protopanaxatriol ginseng. Journal of Dalian Polytechnic University. 2010, 28(4): 258- 260.
    • Ying Wang, Yaoyao Fu, Tingqiang Liu, Hongshan Yu, Fengxie Jin. Extraction of diosgenin from Dioscorea zingiberensis C.H. Wright. Journal of Anhui Agricultural Sciences. 2010, 38(3):1616-1617, 1645.
    • Ying Wang, Yaoyao Fu, Tingqiang Liu, Hongshan Yu, Fengxie Jin. Fermentation of enzyme transforming dioscin to its aglycone. Journal of Dalian Polytechnic University. 2010, 29(3): 157-160.
    • Xuelong Li, Yaoyao Fu, Siyi Sun, Shaoping Fu, Hongshan Yu, Fengxie Jin. Producing ginsenoside Rg3 by exoenzyme producing from new bacteria Arthrobacter sp.3 strain. Journal of Dalian Polytechnic University. 2010, 29(6): 396-398.
    • Jiantao Chang, Yaoyao Fu, Di Wu, Hongshan Yu, Fengxie Jin. Comparation of ginsenosides from different parts in Dunhua ginseng. Journal of Dalian Polytechnic University. 2011, 30(1): 43-45.
    • Longhua Li, Yaoyao Fu, Ling Shi, Yufeng Xu, Hongshan Yu, Fengxie Jin. Separation and Purification of Ginsenoside Rh1 in Panax notoginseng. Journal of Dalian Polytechnic University. 2011, 30(1): 23-25.

     

  • Jung, Saet-Byel
  • Senior Researcher
  • saetbyelibs.re.kr

Detail

  • Information
  •  

    Educations

    • 2000 B.S. Department of Microbiology, Chungnam National University, Daejeon, South Korea.
    • 2002 M.S. Department of Microbiology, Chungnam National University, Daejeon, South Korea.
    • 2006 Ph.D. Department of Medicine, Chungnam National University, Daejeon, South Korea.   

     

     

     

    Careers

    • 2006-2010 Postdoctoral Fellow, Cardiovascular Institute, University of Pittsburgh, USA.
    • 2010-2011 Research Professor, Cardiovascular Institute, University of Pittsburgh, USA.
    • 2011-2018 Research Professor, Research Institute for Medical Sciences, Chungnam National University, Daejeon, South Korea.
    • 2018-2019 Research Professor, Research Institute for Neuroscience, Chungnam National University, Daejeon, South Korea.

     

     

     

    Publications

    • ㆍChoi MJ, Jung SB, Lee SE, Kang SG, Lee JH, Ryu MJ, Chung HK, Chang JY, Kim YK, Hong HJ, Kim H, Kim HJ, Lee CH, Mardinoglu A, Yi HS, Shong M. An Adipocyte-specific defect in oxidative phosphorylation increases systemic energy expewnditure and protects against diet-induced obesity in mouse medels. Diabetologia. 2020 Jan 10. doi: 10.1007/s00125-019-05082-7.
    • Jung SB, Choi MJ, Ryu D, Yi HS, Lee SE, Chang JY, Chung HK, Kim YK, Kang SG, Lee JH, Kim KS, Kim HJ, Kim CS, Lee CH, Williams RW, Kim H, Lee HK, Auwerx J, Shong M. Reduced oxidative capacity in macrophages results in systemic insulin resistance. Nat Commun. 2018 Apr 19;9(1):1551. doi: 10.1038/s41467-018-03998-z.
    • ㆍLee SE, Kang SG, Choi MJ, Jung SB, Ryu MJ, Chung HK, Chang JY, Kim YK, Lee JH, Kim KS, Kim HJ, Lee HK, Yi HS, Shong M. Growth Differentiation Factor 15 Mediates Systemic Glucose Regulatory Action of T-Helper Type 2 Cytokines. Diabetes. 2017 Nov;66(11):2774-2788. doi: 10.2337/db17-0333.
    • ㆍVikram A, Lewarchik CM, Yoon JY, Naqvi A, Kumar S, Morgan GM, Jacobs JS, Li Q, Kim YR, Kassan M, Liu J, Gabani M, Kumar A, Mehdi H, Zhu X, Guan X, Kutschke W, Zhang X, Boudreau RL, Dai S, Matasic DS, Jung SB, Margulies KB, Kumar V, Bachschmid MM, London B, Irani K. Sirtuin 1 regulates cardiac electrical activity by deacetylating the cardiac sodium channel. Nat Med. 2017 Mar;23(3):361-367. doi: 10.1038/nm.4284.
    • ㆍKang SG, Yi HS, Choi MJ, Ryu MJ, Jung SB, Chung HK, Chang JY, Kim YK, Lee SE, Kim HW, Choi H, Kim DS, Lee JH, Kim KS, Kim HJ, Lee CH, Oike Y, Shong M. ANGPTL6 expression is coupled with mitochondrial OXPHOS function to regulate adipose FGF21. J Endocrinol. 2017 Apr;233(1):105-118. doi: 10.1530/JOE-16-0549.
    • ㆍChung HK, Ryu D, Kim KS, Chang JY, Kim YK, Yi HS, Kang SG, Choi MJ, Lee SE, Jung SB, Ryu MJ, Kim SJ, Kweon GR, Kim H, Hwang JH, Lee CH, Lee SJ, Wall CE, Downes M, Evans RM, Auwerx J, Shong M. Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis. J Cell Biol. 2017 Jan 2;216(1):149-165. doi: 10.1083/jcb.201607110.
    • Jung SB, Nagar H, Kwon SK, Park JB, Shong M, Song HJ, Jeon BH, Irani K, Kim CS. CRIF1 deficiency induces p66shc-mediated oxidative stress and endothelial activation. PLoS One. 2014 Jun 6;9(6):e98670. doi: 10.1371/journal.pone.0098670. eCollection 2014.
    • Jung SB, Kwon SK, Kwon M, Nagar H, Jeon BH, Irani K, Yoon SH, Kim CS. Docosahexaenoic acid improves vascular function via up-regulation of SIRT1 expression in endothelial cells. Biochem Biophys Res Commun. 2013 Jul 19;437(1):114-9. doi: 10.1016/j.bbrc.2013.06.049. Epub.
    • Jung SB, Kim CS, Kim YR, Naqvi A, Yamamori T, Kumar S, Kumar A, Irani K. Redox factor-1 activates endothelial SIRTUIN1 through reduction of conserved cysteine sulfhydryls in its deacetylase domain. PLoS One. 2013 Jun 3;8(6):e65415. doi: 10.1371/journal.pone.0065415.
    • Jung SB, Kim CS, Naqvi A, Yamamori T, Mattagajasingh I, Hoffman TA, Cole MP, Kumar A, Dericco JS, Jeon BH, Irani K. Histone deacetylase 3 antagonizes aspirin-stimulated endothelial nitric oxide production by reversing aspirin-induced lysine acetylation of endothelial nitric oxide synthase. Circ Res. 2010 Oct 1;107(7):877-87. doi: 10.1161/CIRCRESAHA.110.222968.

     

  • Yang, Jimin
  • Senior Researcher
  • yangj79ibs.re.kr

Detail

  • Information
  • Educations

    • 2002 B.S. Department of Microbiology, Chungnam National University, Daejeon, South Korea.
    • 2004 M.S. Department of Microbiology, Chungnam National University, Daejeon, South Korea.
    • 2017 Ph.D. Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul National University, Seoul, South Korea.

     

     

    Careers

    • 2006-2010 Research Professor, Biomedical Research Institute, Seoul National University Hospital, Seoul, South Korea.
    • 2019-2020 Postdoctoral Fellow, Vascular Medicine Institute, University of Pittsburgh Medical Center, University of Pittsburgh, USA.

     

     

    Publications

    • Hyun-Duk Jang*, Sang Eun Lee*, Jimin Yang*, Hyun-Chae Lee, Dasom Shin, Hwan Lee, Jaewon Lee, Sooryeonhwa Jin, Soungchan Kim, Ky-Youb Nam, Sang-Hak Lee, Sahng Wook Park, Jin-Soo Kim, Hyo-Soo Kim. Cyclase-associated protein 1 is a binding partner of proprotein convertase subtilisin/kexin type-9 and is required for the degradation of low-density lipoprotein receptors by proprotein convertase subtilisin/kexin type-9:Eur. Heart J.2020. 41(2):239-252.
    • Seo-Yeon Lee*, Jimin Yang*, Jung Hwa Park, Hwa Kyoung Shin, Woo Jean Kim, Su Yeon Kim, Eun Ju Lee, Injoo Hwang, Choon-Soo Lee,Jaewon Lee, and Hyo-Soo Kim. The MicroRNA-92a/Sp1/MyoD Axis Regulates Hypoxic Stimulation of Myogenic Lineage Differentiation in Mouse Embryonic Stem Cells: Molecular Therapy; 2019, 28(1) :142-156.
    • Jimin Yang*, Woo Jean Kim*, Hyoung Oh Jun, Eun Ju Lee, Kyeong Won Lee, Jae-Yeon Jeong and Sae-Won Lee. Hypoxia-induced fibroblast growth factor 11 stimulates capillary-like endothelial tube formation: ONCOLOGY REPORTS, 2015, 34: 2745-2751.
    • Jimin Yang*, Sae-Won Lee*, Su-Yeon Kim, Han-Kyul Jeong, Jaewon Lee, Woo Jean Kim, Eun Ju Lee, Hyo-Soo Kim. MicroRNA-26a induced by hypoxia targets HDAC6 in myogenic differentiation of embryonic stem cells: Nucleic Acids Research,2015, 43; 4: 2057–2073
    • Jimin Yang*, Jin Hur*, Jae-Il Choi*, Ji-Yeon Yun, Jae Hee Jang, Joonoh Kim, Ju-Young Kim, Il-Young Oh, Chang-Hwan Yoon, Hyun-Jai Cho, Young-Bae Park, Hyo-Soo Kim. New method to differentiate human peripheral blood monocytes into insulin producing cells: Human hematosphere culture: Biochem Biophys Res Commun, 2012,418; 4:765-769.

     

     

  • Min, Kwang Wook
  • Postdoctoral Research Associates
  • kwminibs.re.kr

Detail

  • Information
  •  

    Educations

    • ㆍ 2007-2011 B.S. Biochemistry, Chungbuk National University.   
    • 2012-2020 Ph.D. Department of Biological Sciences, KAIST.     

     

    Careers

    • ㆍ 2020 Postdoctoral Fellowship, KAIST.       

     

    Publications

    • Kwang Wook Min, Namsuk Kim, Jae Hoon Lee, Younghoon Sung, Museong Kim, Eun Jung Lee, Jaeyoung Lee, Jong-Myeong Kim, Jee Myung Yang, Seung-Hee Lee, Han Woong Lee, and Jin Woo Kim. (2020) Inverse oculomotor response of achiasmatic mice expressing a transfer-defective Vax1 mutant. BioRxiv (under revision in eLife).
    • ㆍ Dai Le, Soyeon Lim, Kwang Wook Min, Joon Woo Park, Youjoung Kim, Taejeong Ha, Kyeong Hwan Moon, Kay-Uwe Wagner, Jin Woo Kim. (2021) Tsg101 is necessary for the establishment and maintenance of mouse retinal pigment epithelial cell polarity. Mol Cells.
    • Hyoung-Tai Kim, Soung Jung Kim, Young-In Sohn, Sun-Sook Paik, Romain Caplette, Manuel Simonutti, Kyeong Hwan Moon, Eun Jung Lee, Kwang Wook Min, Mi Jeong Kim, Dong-Gi Lee, Antonio Simeone, Thomas Lamonerie, Takahisa Furukawa, Jong-Soon Choi, Hee-Seok Kweon, Serge Picaud, In-Beom Kim, Minho Shong and Jin Woo Kim. (2015) Mitochondrial Protection by Exogenous Otx2 in Mouse Retinal Neurons. Cell report.
    • Namsuk Kim, Kwang Wook Min, Kyung Hwa Kang, Eun Jung Lee, Hyoung-Tai Kim, Kyunghwan Moon, Jiheon Choi,Dai Le,Sang-Hee Lee and Jin Woo Kim. (2014) Regulation of retinal axon growth by secreted Vax1 homeodomain protein. eLife.     
  • Jo, Gyunghee
  • Postdoctoral Research Associates
  • kyungheekaist.ac.kr

Detail

  • Information
  •  

    Educations

    • ㆍ 2011-2016 B.S. Department of System Immunology, Kangwon National University.  
    • ㆍ 2016-2018 M.S. Department of System Immunology, Kangwon National University.
    • ㆍ 2018-2021 Ph.D. Graduate School of Medical Science & Engineering, KAIST.

     

    Careers

    •       

     

    Publications

    • ㆍ Gyunghee Jo, Jeomil Bae, Ho Jeong Hong, Ah-reum Han, Do-Kyun Kim, Jung A Kim, Sangkyu Lee, Gou Young Koh, Ho Min Kim. Structural insights into the clustering and activation of Tie2 receptor. NATURE COMMUNICATIONS, (under revision).
    • ㆍ Suyeong Han, Yu-na Kim, Gyunghee Jo, Young Eun Kim, Ho Min Kim, Jeong-Mo Choi, Yongwon Jung. Multivalent-Interaction-Driven Assembly of Discrete, Flexible, and Asymmetric Supramolecular Protein Nano-Prisms. ANGEWANDTE CHEMIE, 2020.
    • ㆍ Dain Kim, Jisu Hong, Yoonjoo Choi, Jemin Han, Sang Kyu Kim, Gyunghee Jo, Jun-Yeol Yoon, Heesu Chae, Hyeseon Yoon, Chankyu Lee, Hyo Jeong Hong. Generation and Characterization of Monoclonal Antibodies to the Ogawa Lipopolysaccharide of Vibrio cholerae O1 from Phage-Displayed Human Synthetic Fab Library. JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 2020.
    • ㆍ Dain Kim, Hyeseon Yoon, Sang Kyu Kim, Jimin Wi, Heesu Chae, Gyunghee Jo, Jun-Yeol Yoon, Heeyoun Kim, Chankyu Lee, Se-Ho Kim, Hyo Jeong Hong. Generation of a Human Monoclonal Antibody to Cross-Reactive Material 197 (CRM197) and Development of a Sandwich ELISA for CRM197 Conjugate Vaccines. JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 2018.
    • Gyunghee Jo, Mun Sik Jeong, Jimin Wi, Doo Hyun Kim, Sang Kyu Kim, Dain Kim, Jun-Yeol Yoon, Heesu Chae, Kyun-Hwan Kim, Hyo Jeong Hong. Generation and Characterization of a Neutralizing Human Monoclonal Antibody to Hepatitis B Virus PreS1 from a Phage-Displayed Human Synthetic Fab Library. JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 2018. 
    • ㆍ Jun-Yeol Yoon, Dong Hwan Kim, Sangkyu Kim, Dain Kim, Gyunghee Jo, Moon-Sik Shin, Jeongha Yoo, Heui Keun Kang, Min Soo Kim, Young-Jin Kim, Nam-Taek Lee, Hyo Jeong Hong, Yoon-Won Kim. Generation of a monoclonal antibody that has reduced binding activity to VX-inactivated butyrylcholinesterase (BuChE) compared to BuChE by phage display. BIOTECHNOLOGY AND BIOPROCESS ENGINEERING, 2017.     

     

  • Ro, Hyun-Joo
  • Researcher
  • nhj0229ibs.re.kr

Detail

  • Information
  • Educations

    • ㆍ2012-2016 B.S. Biology and mathematics, Australian National University, Canberra, AUSTRALIA.
    • ㆍ2017-2019 M.S. Bio-analytical science (electron microscopy), UST, Daejeon, KOREA.

     

    Publications

    •  Jung, E., Nam, S., Oh, H., Jun, S., Ro, H., Kim, B., Kim, M. and Go, Y. (2019). Neutralization of Acidic Intracellular Vesicles by Niclosamide Inhibits Multiple Steps of the Dengue Virus Life Cycle In Vitro. Scientific Reports, 9(1).
    • ㆍJun, S., Ro, H., Bharda, A., Kim, S., Jeoung, D. and Jung, H. (2019). Advances in Cryo-Correlative Light and Electron Microscopy: Applications for Studying Molecular and Cellular Events. The Protein Journal.
    • ㆍHeo, J., Son, Y., Han, S., Ro, H., Jun, S., Kundapur, U., Noh, J. and Kim, J. (2019). Thermochromic Polydiacetylene Nanotube from Amphiphilic Macrocyclic Diacetylene in Aqueous Solution. Macromolecules, 52(11), pp.4405-4411.
    • ㆍBae, J., Jung, D., Jeong, C., Kim, H., Kim, J., Ro, H., Jun, S., Kim, D., Kim, J., Yi, G., Lee, G. and Chang, K. (2019). Influence of Morphological Homogeneity of Superspherical Gold Nanoparticles on Plasmonic Photothermal Heat Generation. Particle & Particle Systems Characterization, 36(7), p.1900131.
    • ㆍIm, E., Lee, C., Moon, P., Rangaswamy, G., Lee, B., Lee, J., Lee, J., Jee, J., Bae, J., Kwon, T., Kang, K., Jeong, M., Lee, J., Jung, H., Ro, H., Jun, S., Kang, W., Seo, S., Cho, Y., Song, B. and Baek, M. (2019). Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A. Nature Communications, 10(1).
    • ㆍYun, S., Park, E., Lee, S., Lee, H., Choi, C., Yi, Y., Ro, H., Lee, J., Jun, S., Kim, H., Kim, G. and Kim, S. (2018). Antibiotic treatment modulates protein components of cytotoxic outer membrane vesicles of multidrug-resistant clinical strain, Acinetobacter baumannii DU202. Clinical Proteomics, 15(1).
    • Ro, H., Lee, H., Park, E., Lee, C., Il Kim, S. and Jun, S. (2018). Ultrastructural visualization of Orientia tsutsugamushi in biopsied eschars and monocytes from scrub typhus patients in South Korea. Scientific Reports, 8(1).
    • ㆍAhn, S., Jun, S., Ro, H., Kim, J. and Kim, S. (2018). Complete Genome of Bacillus subtilis subsp. subtilis KCTC 3135T and Variation in Cell Wall Genes of B. subtilis Strains. Journal of Microbiology and Biotechnology, 28(10), pp.1760-1765.
    • ㆍYun, S., Lee, S., Choi, C., Lee, H., Ro, H., Jun, S., Kwon, Y., Kwon, K., Kim, S., Kim, G. and Kim, S. (2016). Proteomic characterization of the outer membrane vesicle of the halophilic marine bacterium Novosphingobium pentaromativorans US6-1. Journal of Microbiology, 55(1), pp.56-62.

     

  • Cho, Hyun-ju
  • Senior Researcher(YSF)
  • hjchoibs.re.kr

Detail

  • Information
  • Educations

    • ㆍ2002 B.S. Chemical Engineering, Pusan National University, Pusan, Korea.
    • 2004 M.S. Chemical and Biomolecular Engineering, KAIST, Dea-Jeon, Korea.
    • 2013 Ph.D. Chemical Engineering, Michigan State University, East Lansing, MI, USA.

     

    Careers

    • 2004-2007 Researcher, KIST, Seoul, Korea.
    • 2007-2014 Research Assistant, Michigan State University, East Lansing, MI, USA.
    • 2014-2020 Postdoctoral Researcher, California Institute of Technology, Pasadena, CA, USA.

     

    Publications

    • Hyunju Cho*,#, Francesca Stanzione*, Amrita Oak*, Geun Hyang Kim, Sindura Yernen, Ling Qi, Amadeu K. Sum, Christina Chan# (2019) “Intrinsic structural features of the human IRE1α transmembrane domain sense membrane lipid saturation” Cell Reports 27(1):307-320.e5 (Co-first author* and Co-corresponding author#)
    • Hyunju Cho, Un Seng Chio, Shu-ou Shan (2018) “In vitro Assays for Targeting and Insertion of Tail‐Anchored Proteins Into the ER Membrane” Current Protocols in Cell Biology e63. doi: 10.1002/cpcb.63. (First author)
    • Hyunju Cho, Shu-ou Shan (2018) “Substrate relay in an Hsp70-cochaperone cascade safeguards tail-anchored membrane protein targeting” EMBO Journal 37(16). pii: e99264. (First author)
    • Hyunju  Cho*,  Ming  Wu*,  Linxia  Zhang*,  Ryan  Thompson,  Aritro  Nath,  Christina  Chan  (2013)“Signaling dynamics of palmitate-induced ER stress responses mediated by ATF4 in HepG2 cells” BMC Systems Biology 7(1):9.  (Co-first author)
    • Hyunju Cho, Ryan LaMarca, and Christina Chan (2012) “Oligomerization of the transmembrane domain of IRE1α in SDS micelles” Biochemical and Biophysical Research Communications 427(4):764-767. (First author)
    • Hyunju Cho, Ming Wu, Betul Bilgin, S. Patrick Walton, Christina Chan (2012) “Latest developments in experimental   and   computational   approaches   to   identify   protein-lipid   interactions”   Proteomics 12(22):3273-3285. (First author)
    • Hyunju  Cho, Shayantani  Mukherjee, Pratheeba Palasuberniam,  Lisa  Pillow,  Betul Bilgin,  Catherine Nezich,  S.  Patrick  Walton,  Michael  Feig,  Christina  Chan  (2011)  “Molecular  mechanism  by  which palmitate inhibits PKR autophosphorylation” Biochemistry 50:1110-1119. (First author)
    • Hyunju Cho*, Ho-Youl Lee*, Dae-Ro Ahn, Sang Yoon Kim, Sunyun Kim, Keun Byeol Lee, You Mie Lee, Hyunsung Park, and Eun Gyeong Yang (2008) “Baicalein induces functional Hypoxia-Inducible Factor-1α and angiogenesis” Molecular Pharmacology 74:70–81. (Co-first author)
    • Hyunju Cho, Dae-Ro Ahn, Hyunsung Park, Eun Gyeong Yang  (2007) “Modulation of p300 binding by posttranslational modifications of the C-terminal activation domain of hypoxia-inducible factor-1alpha” FEBS Letter 581: 1542-1548. (First author)
    • Hyunju  Cho,  Hyunsung  Park  and  Eun  Gyeong  Yang  (2005)  “A  fluorescence  polarization-based interaction  assay  for  hypoxia-inducible  factor  prolyl  hydroxylases”  Biochemical  and  Biophysical Research Communications 337: 275-280.  (First author)

     

  • Rathnasingh, Christy Catherine
  • Postdoctoral Research Associates(YSF)
  • christyibs.re.kr

Detail

  • Information
  •  

    Educations

    • ㆍ2018 Ph.D Applied Chemistry and Biological Engineering, Chungnam National University, Daejeon, South Korea.

     

     

     

    Publications

    • Devi Kasi, Christy Catherine, Seung-won Lee, Kyung-Ho Lee, Yu Jung Kim, Myeong Ro Lee, Jung Won Lee, Dong-Myung Kim (2017) Cell-free translational screening of an expression sequence tag library of Clonorchis sinenesis for novel antigen discovery, Biotechnology Progress, DOI 10.1002/btpr.2440.
    • Christy Catherine, Seung-won Lee, Jung Won Ju, Ho-Cheol Kim, Hyung-II Shin, Yu Jung Kim, Dong-Myung Kim (2015) Cell-free expression and In situ immobilization of parasite proteins from Clonorchis sinensis for rapid identification of antigenic candidates. Plos One. DOI: 10.1371/journal.pone.0143597.
    • Christy Catherine, Su-Jin Oh, Kyung-Ho Lee, Seung-Eui Min, Jong-In Won, Hyungdon Yun, Dong-Myung Kim (2015) Engineering thermal properties of elastin-like polypeptides by incorporation of unnatural amino acids in a cell-free protein synthesis system. Biotechnology and Bioprocess Engineering 21:417-422.
    • Su-Jin Oh, Kyung-Ho Lee, Ho-Cheol Kim, Christy Catherine, Hyungdon Yun, Dong-Myung Kim (2014) Translational incorporation of multiple unnatural amino acids in a cell-free protein synthesis system. Biotechnology and Bioprocess Engineering 19:426-432.
    • Christy Catherine, Kyung-Ho Lee, Su-Jin Oh, Dong-Myung Kim (2013) Cell-free platforms for flexible expression and screening of enzymes. Biotechnology advances 31:797-803.
    • Shengfang Zhou, Christy Catherine, Chelladurai Rathnasingh, Ashok Somasundar, Sunghoon Park (2013) Production of 3-hydroxypropionic acid from glycerol by recombinant Pseudomonas denitrificans. Biotechnology and Bioengineering 110(12):3177-3187.
    • Christy Catherine, Greety Sunitha, Prabalakshmi P, Sheela Devi (2009) Antibacterial activity and preliminary phytochemical analysis of the herbal plat, Vitex agnus. Journal of Bloomers research 1(2):140-146.
    • Chelladurai Rathnasingh, Subramanian Mohan Raj, Youjin Lee, Christy Catherine, Somasundar Ashok, Sunghoon Park (2011) Production of 3-hydroxypropionic acid via malonyl-CoA pathway using recombinant Escherichia coli strains. Journal of Biotechnology 157(4):633-40.

     

  • Oh, Jeong-hyun
  • Researcher(YSF)
  • ojh5017ibs.re.kr

Detail

  • Information
  •  

    Educations

    • ㆍ2017 B.S. Department of Electric Engineering, Chungnam National University, Daejeon, South Korea.
    • ㆍ2020 M.S. Graduate School of Analytical Science & Technology, Chungnam National University, Daejeon, South Korea.

     

     

     

    Publications

    •  Jong-Soon Choi, Yun Hwan Park, Jeong Hyun Oh, Sooyong Kim, Joseph Kwon, Yoon-E Choi. Efficient profiling of detergent-assisted membrane proteome in cyanobacteria.Journal of Applied Phycology, 32 (2020) pages 1177-1184.

     

  • Kim, Hyo Jin
  • Graduate Student, MS-PhD program, Biomedical Science and Engineering Interdisciplinary Program, KAIST
  • kimyo917kaist.ac.kr

Detail

  • Information
  •  

    Educations

    • ㆍ 2014-2018 B.S. Department of Genetic Engineering, Kyunghee University.

     

  • Yun, Jeong Won
  • Graduate Student, MS-PhD program, Biomedical Science and Engineering Interdisciplinary Program, KAIST
  • jeongw315kaist.ac.kr

Detail

  • Information
  • Educations

    • ㆍ2011-2019 B.S. College of Biochemistry, Chungnam National University.

     

  • Kim, So Hyun
  • Graduate Student, MS-PhD program, Biomedical Science and Engineering Interdisciplinary Program, KAIST
  • shkim20kaist.ac.kr

Detail

  • Information
  • Educations

    • ㆍ2015-2020 B.S. Department of Chemistry, UNIST.

     

  • Cho, Ryeongeun
  • Graduate Student, PhD program, Biomedical Science and Engineering Interdisciplinary Program, KAIST
  • whfuddmskaist.ac.kr

Detail

  • Information
  • Educations

    • 2014-2018 B.S. Department of Chemical & Biomolecular Engineering, KAIST.
    • ㆍ2018-2020 M.S. Department of Chemical & Biomolecular Engineering, KAIST.

     

  • Lim, Mi Na
  • Administrative Staff
  • +82-42-878-8116
  • minalimibs.re.kr

  • Lee, Jee Geon
  • Administrative Staff
  • +82-42-878-9403
  • seeljgibs.re.kr

  • Na-Yeon Kim
  • UNIST 석박통합 과정 학생

  • Hyo-Ju Park
  • UNIST 석박통합 과정 학생

  • Tai-Young Kim
  • Senior Researcher
  • Cholesteol metablisim in glioblastoma, Indentification of interacting proteins using BioID
  • taikibs.re.kr

Detail

  • Information
  • Tai Young Kim

    • Senior Researcher
    • Cholesteol metablisim in glioblastoma, Indentification of interacting proteins using BioID, Drug development against COVID-19 coronavirus (SARS-CoV-2)

    • taik@ibs.re.kr


    EDUCATION

    2002             Ph.D. in Tumor Biology, Seoul National University, College of Medicine, Korea (advisor: Yung-Jue Bang)

    1996             M.S. in Microbiology, Seoul National University, Korea (advisor: Gajin Jeong)

    1993             B.S. in Microbiology, Hankuk University of Foreign Studies, Korea.

     

    PROFESSIONAL EXPERIENCES

    06/2020 – Current    Senior Researcher, Center for Cognitive and Sociality, Institute for Basic Science, Daejeon, Korea

    01/2019 – 05/2020   Research Fellow, Cognitive Glioscience Group, Center for Cognitive and Sociality, Institute for Basic Science, Daejeon,

                                Korea

    11/2015 – 12/2018   Research Professor, Kyung Hee University Korean Medicine, Korea.

    01/2014 – 10/2015   Principal Research Scientist, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National

                                University, Korea.

    08/2013 – 12/2013   Research Associate Professor, School of Nano-Bioscience and Chemical Engineering, UNIST, Republic of Korea

    01/2009 - 07/2013   Postdoctoral Research Associate, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC

                                (Advisor: Channing J. Der)

    01/2004 - 12/2008   Postdoctoral Research Associate, Department of Pharmacology, University of North Carolina, Chapel Hill, NC

                                (Advisor:  Rudy L. Juliano)

    08/2002 - 12/2003   Postdoctoral Research Associate, Cancer Research Institute, Seoul National University, Korea (advisor: Yung-Jue Bang)

    07/1998 - 03/1999   M.S. Researcher, Cancer Research Institute, Seoul National University, Korea

     

    AWARDS and FELLOWSHIPS

    2016-2019    Research Fellow Grant, Ministry of Education, Korea of Republic

    2013–2016    Research Fellow Grant, Ministry of Education, Korea of Republic

    2009-2011    Susan G. Komen Research Grant

    2003            Young Researcher Awards in Seoul National University Cancer Research Institute

     

    PUBLICATION

    1. Jang MW, Oh D, Yi E, Liu X, Ling J, Kim N, Sharma K, Kim TY, Lee S, Kim AR, Kim MY, Kim MA, Lee M, Han JH, Han JJ, Park HR, Kim BJ, Lee SY, Woo DH, Oh J, Oh SJ, Du T, Koo JW, Oh SH, Shin HW, Seong MW, Lee KY, Kim UK, Shin JB, Sang S, Cai X, Mei L, He C, Blanton SH, Chen ZY, Chen H, Liu X, Nourbakhsh A, Huang Z, Kang KW, Park WY, Feng Y, Lee CJ, Choi BY (2021) A nonsense TMEM43 variant leads to disruption of connexin-linked function and autosomal dominant auditory neuropathy spectrum disorder. Proc Natl Acad Sci, USA. Jun 1;118(22)

    2. Kim TY, Jeon S, Jang Y, Gotina L, Won J, Ju YH, Kim S, Jang MW, Won W, Park MG, Pae AN, Han S, Kim ST, Lee CJ (2021) Platycodin D, a natural product from Platycodon grandiflorum, prevents both lysosome- and TMPRSS2-driven SARS-CoV-2 infection by hindering membrane fusion. Exp Mol Med, May;53(5):956-972

    3. Lee SJ, Choi YJ, Kim HI, Moon HE, Baek SH, Kim TY, Ko SG (2021) LDLR facilitates platycodin D-induced autophagy inhibition.and cell death in glioblastoma cells. Mol Oncol. May 1 *Co-corresponding Author.

    4. Kim HI, Lee SJ, Choi YJ, Kim MJ, Kim TY, Ko SG (2021) Quercetin induces apoptosis in glioblastoma cell lines U87MG and U373MG by suppressing Axl/IL-6/STAT3 signaling pathway. Am J Chin Med, Mar 3;1-18. *Co-corresponding Author

    5. Choi YJ, Lee SJ, Kim HI, Lee HJ, Kang SJ, Kim TY, Cheon C, Ko SG. (2020) Platycodin D enhances LDLR expression and LDL uptake via down-regulation of IDOL mRNA in hepatic cells. Sci Rep, Nov 16;10(1):1983. *Co-corresponding Author

    6. Won J, Lee S, Park M, Kim TY, Park MG, Choi BY, Kim D, Chang H, Kim VN, Lee CJ (2020) Development of a Laboratory-safe and Low-cost Detection Protocol for SARS-CoV-2 of the Coronavirus Disease 2019 (COVID-19). Exp Neurobiol, Apr 30; 29(2):107-119.

    7. Hong SH, Ku JM, Kim HI, Kim TY, Seo HS, Shin YC, Ko SG (2019) Topical Application of KAJD Attenuates 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis Symptoms Through Regulation of IgE and MAPK Pathways in BALB/C Mice and Several Immune Cell Types. Front Pharmacol. Sep 19; 10:1097.

    8. Kim HI, Hong SH, Ku JM, Lim YS, Lee SJ, Song J, Kim TY, Cheon C, Ko SG. (2019) Scutellaria Radix Promotes Apoptosis in Non-Small Cell Lung Cancer Cells via Induction of AMPK-Dependent Autophagy. Am J Chin Med. 47(3):691-705

    9. Ku JM, Hong SH, Kim SR, Choi HS, Kim HI, Kim DU, Oh SM, Seo HS, Kim TY, c, Cheon C, Ko SG. (2018) Novel mechanism The prevention of 2,4-dinitrochlorobenzene-induced inflammation in atopic dermatitis-like skin lesions in BALB/c mice by Jawoongo. BMC Complement Altern Med. Jul 13;18(1):215

    10. Kim HI, Hong SH, Ku JM, Kang S, Kim TY, Shin YC, Ko SG. (2017) Tonggyu-tang, a traditional Korean medicine, suppresses pro-inflammatory cytokine production through inhibition of MAPK and NF-κB activation in human mast cells and keratinocytes. BMC Complement Altern Med. Mar 31;17(1):186

    11. Kim HJ, Kwon S, Nam SH, Jung JW, Kang M, Ryu J, Kim JE, Cheong JG, Cho CY, Kim S, Song DG, Kim YN, Kim TY, Jung MK, Lee KM, Pack CG, Lee JW. (2017) Dynamic and coordinated single-molecular interactions at TM4SF5-enriched microdomains guide invasive behaviors in 2- and 3-dimensional environments.FASEB J. 2017, 31(4):1461-1481.

    12. Choi J, Kang M, Nam SH, Lee GH, Kim HJ, Ryu J, Cheong JG, Jung JW, Kim TY, Lee HY, Lee JW (2015) Bidirectional signaling between TM4SF5 and IGF1R promotes resistance to EGFR kinase inhibitors. Lung Cancer, 90(1):22-31

    13. Nam SH, Kim D, Lee MS, Lee D, Kwak TK, Kang MK, Ryu J, Kim HJ, Song HE, Choi J, Lee GH, Kim SY, Park SH, Kim DG, Kwon NH, Kim TY, Thiery JP, Kim S, and Lee JW (2015) Noncanonical roles of membranous lysyl-tRNA synthetase in transducing cell-substrate signaling for invasive dissemination of colon cancer spheroids in 3D collagen I gels. Oncotarget, 6(25): 21655-74

    14. Lee D, Na J, Ryu J, Kim HJ, Nam SH, Kang M, Jung JW, Lee MS, Song HE, Choi J, Lee GH, Kim TY, Chung JK, Park KH, Kim SH, Kim H, Seo H, Kim P, Youn H, Lee JW (2015) Interaction of tetraspan(in) TM4SF5 with CD44 promotes self-renewal and circulating capacities of hepatocarcinoma cells. Hepatology, 61(6):1978-97

    15. Kim TY, Seisser PM, Rossman KL, Goldfarb D, Mackinnon K, Yan F, Yi X, MacCoss, M, Moon RT, Der CJ, Major MB (2015) Substrate Trapping Proteomics Reveals Targets of the βTrCP2/FBXW11 Ubiquitin Ligase. Mol Cell Biol, 35(1):167-81

    16. Kang M, Ryu J, Lee D, Lee MS, Kim HJ, Nam SH, Song HE, Choi J, Lee GH, Kim TY, Lee H, Kim SJ, Ye SK, Kim S, Lee JW (2014) Correlations between Transmembrane 4 L6 Family Member 5 (TM4SF5), CD151, and CD63 in Liver Fibrotic Phenotypes and Hepatic Migration and Invasive Capacities. PLoS One. 9(7):e102817

    17. Lee MS, Kim S, Kim BG, Won C, Nam SH, Kang S, Kim HJ, Kang M, Ryu J, Song HE, Lee D, Ye SK, Jeon NL, Kim TY, Cho NH, Lee JW (2014) Snail1 induced in breast cancer cells in 3D collagen I gel environment suppresses cortactin and impairs effective invadopodia formation. Biochim Biophys Acta. 1843(9):2037-54

    18. Kim TY, Jackson S, Xiong Y, Whitsett TG, Lobello JR, Tran NL, Malek NP, Bang YJ, Der CJ (2013) Loss of DLC1 RhoGAP tumor suppressor expression and function by CUL4A-DDB1-FBXW5-dependent ubiquitination and degradation in non-small cell lung cancer cells. Proc Natl Acad Sci, USA. 110(42):16868-73 

    19. Vigil D, Kim TY, Plachco A, Garton AJ, Castaldo L, Pachter JA, Dong H, Chen X, Tokar B, Campbell SL, Der CJ (2012) ROCK1 and ROCK2 are required for Non-Small Cell Lung Cancer Anchorage-Independent Growth and Invasion. Cancer Res. 72(20):5338-47

    20. Kim TY, Vigil D, Der CJ, Juliano RL (2009) Role of DLC-1, a Tumor Suppressor Protein with RhoGAP activity, in Regulation of the Cytoskeleton and Cell Motility. Cancer Metastasis Reviews28(1-2):77-83.

    21. Kim TY, Kim IS, Jong HS, Lee JW, Kim TY, Jung M, and Bang YJ. (2008) Transcriptional Induction of DLC-1 gene through Sp1 sites by histone deacetylase inhibitors in gastric cancer cells. Exp Mol Med 40 (6):639-46.

    22. Kim TY, Healy KD, Der CJ, Sciaky N, Bang YJ, Juliano RL (2008) Effects of Structure of Rho GTPase-activating Protein DLC-1 on Cell Morphology and Migration. J Biol Chem 283(47): 32762-70.

    23. SchrampM, Ying O, Kim TY, Martin GS. (2008) ERK5 Promotes Src-induced Podosome Formation by limiting Rho activation. J Cell Biol. 181(7):1195-210.

    24. Healy KD, Hodgson L, Kim TY, Shutes A, Maddileti S, Juliano RL, Hahn KM, Harden TK, Bang YJ, Der CJ. (2008) DLC-1 Suppresses Non-Small Cell Lung Cancer Growth and Invasion by RhoGAP-Dependent and Independent Mechanisms. Mol Carcinog. 47(5):326-37.

    25. Jung Y, Park J, Kim TY, Park JH, Jong HS, Im SA, Robertson KD, Bang YJ, Kim TY. (2007). Potential advantages of DNA methyltransferase 1 (DNMT1)-targeted inhibition for cancer therapy. J Mol Med. 85(10):1137-48.

    26. Kim TY, Lee JW, Kim HP, Jong HS, Kim TY, and Bang YJ. (2007) DLC-1, a GTPase-activating protein for Rho, is associated with cell proliferation, morphology, and migration in human hepatocellular carcinoma. Biochem Biophys Res Commun. 355(1):72-7.

    27. Lee KW, Kim JH, Park JH, Kim HP, Song SH, Kim SG, Kim TY, Jong HS, Jung KH, Im SA, Kim TY, Kim NK, Bang YJ. (2006). Antitumor Activity of SK-7041, a Novel Histone Deacetylase Inhibitor, in Human Lung and Breast Cancer Cells. Anticancer Res. 26(5A):3429-38.

    28. Lee SY, Kim TY, Lee MS, Kim YB, Chung E, Kim S, Lee JW. (2006). Focal adhesion and actin organization by a cross-talk of TM4SF5 with integrin alpha2 are regulated by serum treatment. Exp Cell Res. 312(16):2983-99.

    29. Juliano RL, Dixit VR, Kang H, Kim TY, Miyamoto Y, Xu D. (2005). Epigenetic manipulation of gene expression: a toolkit for cell biologists. J. Cell Biol. 169(6):847-57

    30. Kim JH, Lee KW, Jung Y, Kim TY, Ham HS, Jong HS, Jung KH, Im SA, Kim TY, Kim NK, Bang YJ. (2005). Cytotoxic effects of pemetrexed in gastric cancer cells. Cancer Sci. 96(6):365-71.

    31. Kim HP, Kim TY, Lee MS, Jong HS, Kim TY, Lee JW, Bang YJ. (2005). TGF-1-mediated activations of c-Src and Rac1 modulate levels of cyclins and p27Kip1 CDK inhibitor in hepatoma cells replated on fibronectin. Biochim Biophys Acta (BBA)-Mol Cell Res. 1743(1-2):151-61.

    32. Yim HW, Jong HS, Kim TY, Choi HH, Kim SG, Song SH, Kim J, Ko SG, Lee JW, Kim TY, Bang YJ. (2005). Cyclooxygenase-2 Inhibits Novel Ginseng Metabolite-Mediated Apoptosis. Cancer Res. 65(5):1952-60.

    33. Kim TY, Jong HS, Jung Y, Kim TY, Kang GH, Bang YJ. (2004). DNA hypermethylation in gastric cancer. Aliment Pharmacol Ther., 20 (Suppl 1):131-42.

    34. Park JH, Jung Y, Kim TY, Kim SG, Jong HS, Lee JW, Kim DK., Lee JS, Kim NK, Kim TY., Bang Y.J. (2004). Class I Histone Deacetylase-Selective Novel Synthetic Inhibitors Potently Inhibit Human Tumor Proliferation. Clin Cancer Res., 10(15):5271-81.

    35. Choi MC, Jong HS, Kim TY, Song SH, Lee DS, Lee JW, Kim TY, Kim NK, Bang YJ. (2004). AKAP12/Gravin is inactivated by epigenetic mechanism in human gastric carcinoma and shows growth suppressor activity. Oncogene, 23(42):7095-103.

    36. Park J, Song SH, Kim TY, Choi MC, Jong HS, Kim TY, Lee JW, Kim NK, Kim WH, Bang YJ. (2004), Aberrant methylation of integrin beta 4 gene in human gastric cancer cells. Oncogene, 23(19):3474-80.

    37. Kim TY, Lee HS, Hwang KS, Lee, M, Kim JW, Bang YJ, and Kang GH. (2004). Methylation of Runx3 in various types of human cancers and premalignant stages of gastric carcinoma. Lab Invest. , 84(4):479-84.

    38. Kim TY, Jong HS, Song SH, Dimtchev A, Jeong SJ, Lee JW, Kim TY, Kim NK, Jung, M, and Bang Y.J. (2003). Transcriptional silencing of the DLC-1 tumor suppressor gene by epigenetic mechanism in gastric cancer cells Oncogene, 22(25), 3943-3951.

    39. Park JH, Kim TY, Jong HS, Kim TY, Chun YS, Park JW, Lee CT, Jung HC, Kim NK, and Bang YJ. (2003). Gastric Epithelial Reactive Oxygen Species Prevent Normoxic Degradation of Hypoxia-Inducible factor-1 alpha in Gastric Cancer Cells. Clin. Cancer Res., 9(1), 433-440. 

     

     


  • Ki Jung Kim
  • Senior Researcher
  • kjkimibs.re.kr

Detail

  • Information
  • Curriculum Vitae (last updated: 02-25-2022)

     

    PERSONAL AND PROFESSIONAL INFORMATION                           

    Name: Ki Jung Kim, Ph.D.

    Institute for Basic Science: Senior Researcher

    Professional Address: Center for Cognition and Sociality

                                         Institute for Basic Science

                                         55, Expo-ro, Yuseong-gu, Daejeon, 34126

                                         Republic of Korea

    Telephone: +82-10-8371-5855, Fax: +82-42-878-9151

    E-mail: kjkim@ibs.re.kr

    Google Scholar: Ki Jung Kim

     

    EDUCATION                                                              

    Kyung Hee University, Yongin-si, Kyeongggi-do, South Korea

    Bachelor of Science in Genetic Engineering (1996-2000)

     

    Catholic University of Korea, College of Medicine, Seoul, South Korea

    Master of Science in Neuropharmacology (2002-2004)

    Advisor: Prof. Ki-Wug Sung (MD., Ph.D.)

     

    Catholic University of Korea, College of Medicine, Seoul, South Korea

    Ph.D in Neurobiology (2004-2009)

    Advisor: Prof. Ki-Wug Sung (MD., Ph.D.)

     

    RESEARCH AND PROFESSIONAL EXPERIENCE                             

    Research Assistance (Sep. 2002-Apr. 2009)

    Department of Pharmacology

    Catholic University of Korea, College of Medicine

    Seoul, South Korea

     

    Postdoctoral Associate (Jun. 2009-Aug. 2019)

    Department of Physiology

    Medical College of Georgia

    Augusta University, GA, USA

    Supervisor: Dr. Jessica A. Filosa

     

    Senior Research Associate (Sep. 2019- Jun. 2021)

    Department of Physiology

    Medical College of Georgia

    Augusta University, GA, USA

    Principal Investigator: Dr. Jessica A. Filosa

     

    Senior Researcher (Jul. 2021 - Present)

    Center for Cognition and Sociality

    Institute for Basic Science

    55, Expo-ro, Yuseong-gu, Daejeon, 34126

    Republic of Korea

     

    SCIENTIFIC PUBLICATIONS                                               

    PEER REVIEW ARTICLES

    PUBLISHED

    1. Ki Jung Kim, Juan Ramiro Diaz, Jessica L. Presa, Robinson Muller, Michael W. Brands, Mohammad B. Khan, David C. Hess, and Jessica A. Filosa. (2021) Decreased parenchymal arteriole tone in a mouse model of vascular cognitive impairment uncouples vessel-to-neuronal communication. GeroScience. 2021 Jan 7. (https://doi.org/10.1007/s11357-020-00305-x)

    2. *Ramiro-Diaz, JM., *Kim, KJ., Brands, M and Filosa, JA. (2019) Augmented astrocyte microdomain Ca2+ dynamics and parenchymal arteriole tone in angiotensin II-infused hypertensive mice. Glia. 2018 Dec 2. PMID: 30506941. (*Co-First Author).

      1. This article was recommended in F1000 Prime.

    1. Ki Jung Kim, Seung Hyun Jeun and Ki-Wug Sung (2017) Lamotrigine, an antiepileptic drug, inhibits 5-HT3 receptor currents in NCB-20 neuroblastoma cells. Korean J Physiol Pharmacol. Mar;21(2):169-177. PMID: 28280410.

    2. Kim, KJ., Ramiro-Diaz JM., Iddings, JA., Filosa, JA. (2016) Vasculo-Neuronal Coupling: Retrograde Vascular Communication to Brain Neurons. J Neurosci. 36(50):12624-12639. PMID: 27821575.

      1. This article was recommended in Faculty1000.

    1. Kim, KJ., Iddings, JA., Stern, JE., Blanco, V.M., Kirov, SA., Croom, D., Filosa, JA. (2015) Astrocyte contribution to flow/pressure-evoked parenchymal arteriole vasoconstriction. J Neurosci. 27;35(21):8245-57. PMID:26019339.

    2. Iddings, J.A., Kim, KJ., Zhou, Y., Higashimori, H., Filosa, J.A. (2015) Enhanced parenchymal arteriole tone and astrocyte signaling protect neurovascular coupling mediated parenchymal arteriole vasodilation in the spontaneously hypertensive rat. Journal of Cerebral Blood Flow and Metabolism. 35 (7), 1127-1136. PMID:25757753.

    3. Ki Jung Kim, and Jessica A. Filosa. (2012) Advanced in vitro approach to study neurovascular coupling mechanisms in the brain microcirculation. Journal of Physiology Apr 1;590(Pt 7):1757-70. PMID 22310311. 

      1. A perspective article was writing on this paper by Robert Bryan Jr. JPHYSIOL/2012/233718 "No matter - It matters how you slice it".

    1. HyeongSeok Cho, Seung Hyun Jeun, QuingZhong Li, Ki Jung Kim and Ki-Wug Sung. (2012) Involvement of the endocannabinoid system in ethanol-induced corticostriatal synaptic depression. J Pharmacol Sci. 120, 45-49. PMID: 22971846.

    2. QuingZhong Li, HyeongSeok Cho, Seung Hyun Jeun, Ki Jung Kim and Ki-Wug Sung. (2011) Effects of Grape Seed Proanthocyanidin on 5-Hydroxytryptamine3 Receptors in NCB-20 Neuroblastoma Cells. Biol Pharm Bull. 34(7), 1109-1115. PMID: 21720021.

    3.  Jeun, SH., Cho, HS., Kim, KJ., Li, QZ., Sung, K-W. (2009) Electrophysiological Characterization of AMPA and NMDA Receptors in Rat Dorsal Striatum.Korean J Physiol Pharmacol. Jun;13(3):209-14. PMID: 19885039.

     

  • Heeyoung An
  • Postdoc
  • Transdiffernentiation, Treating Spinal Cord Injury (SCI) and neurodegenerative diseases with direct reprogramming of reactive astrocyte into neuron, Bestrophin1 channel expression related synaptic property
  • ahyheeyoungibs.re.kr

Detail

  • Information
  • Education

     

    March 2002 - August 2010           B.A. Korea University

    ü  Major: Business & Administration

    ü  Minor: Law

    September 2013 - present               Ph.D. course, KU-KIST Graduate School of Converging Science and Technology

    ü  Major: NBIT (Advanced educated in Neuroscience)

    Researcher, Center for Cognition and Sociality, Institute for Basic Science (IBS)

     

    Research Experiments

     

    October 2012 - August 2013          Internship at KIST

    ü  Center for Functional Connectomics

     

    Experiment Techniques

     

    Slice patch-clamp recording (Neuron, Astrocyte), Cell patch (Astrocyte, HEK293T), Sniffer patch, Ca2+ imaging, Primary astrocyte culture, Primary neuron culture, Immunohistochemistry, Immunocytochemistry, Confocal microscope imaging, SIM imaging, Imaris 3D rendering, PCR, RT-PCR, DNA/RNA prep, Cloning, Sub-cloning, Stereotaxic surgery (Mouse, Monkey)

     

    Research Interests

     

    ü  Transdiffernentiation, Treating Spinal Cord Injury (SCI) and neurodegenerative diseases with direct reprogramming of reactive astrocyte into neuron

    ü  Bestrophin1 channel expression related synaptic property

     

     

    Publications

     

    1.        Tweety-homolog (Ttyh) Family Encodes the Pore-forming Subunits of the Swelling-dependent Volume-regulated Anion Channel (VRACswell) in the Brain, Han YE, Kwon J, Won J, An H, Jang MW, Woo J, Lee JS, Park MG, Yoon BE, Lee SE, Hwang EM, Jung JY, Park H, Oh SJ, Lee CJ, Exp Neurobiol. 2019 Apr;28(2):183-215

     

    2.        Pharmacological Dissection of Intrinsic Optical Signal Reveals a Functional Coupling between Synaptic Activity and Astrocytic Volume Transient, Junsung Woo, Young-Eun Han, Wuhyun Koh, Joungha Won, Min Gu Park, Heeyoung An, C. Justin Lee, Exp Neurobiol. 2019 Feb;28(1):30-42

     

    3.        Expression of µ-Opioid Receptor in CA1 Hippocampal Astrocytes, Min-Ho Nam, Kyung-Seok Han, Jaekwang Lee, Jin Young Bae, Heeyoung An, Seahyung Park, Soo-Jin Oh, Eunju Kim, Eunmi Hwang, Yong Chul Bae, C. Justin Lee, Exp Neurobiol. 2018 Apr; 27(2): 120–128.

     

    4.        Control of motor coordination by astrocytic tonic GABA release through modulation of excitation/inhibition balance in cerebellum, Woo J, Min JO, Kang DS, Kim YS, Jung GH, Park HJ, Kim S, An H, Known J, Kim J, Shim I, Kim HG, Lee CJ, Yoon BE, Proc Natl Acad Sci U S A. 2018 Apr 24. pii: 1721187115. do (2018)

     

    5.        Cografting astrocytes improves cell therapeutic outcomes in a Parkinson`s disease model, Song JJ, Oh SM, Kwon OC, Wulansari N, Lee HS, Chang MY, Lee E, Sun W, Lee SE, Chang S, An H, Lee CJ, Lee SH, J Clin Invest 2018 Jan 2;128(1):463-482. (2018)

     

    6.        Astrocytic water channel aquaporin-4 modulates brain plasticity in both mice and humans: a potential gliogenetic mechanism underly, J Woo, JE Kim, JJ Im, J Lee, HS Jeong, S Park, S-Y Jung, H An, S Yoon, SM Lim, S Lee, J Ma, EY Shin, Y-E Han, B Kim, EH Lee, L Feng, H Chun, B-E Yoon, I Kang, SR Dager, IK Lyoo and CJ Lee, Molecular Psychiatry advance online publication 27 June 2017; doi:10.1038/mp.2017.113 (2017)

     

    7.        Orai1 and Orai3 in Combination with Stim1 Mediate the Majority of Store-operated Calcium Entry in Astrocytes, Jea Kwon, Heeyoung An, Moonsun Sa, Joungha Won,Jeong Im Shin and C. Justin Lee, Exp Neurobiol 2017 Feb;26(1):42-54. (2017)

     

    8.        Differential Cellular Tropism of Lentivirus and Adeno-Associated Virus in the Brain of Cynomolgus Monkey, An H, Cho DW, Lee SE, Yang YS, Han SC, Lee CJ, Exp Neurobiol 2016 Feb;25(1):48-54. doi: 10.5607/en.2016.25.1.48. (2016)

     

    9.        Networked neural spheroid by neuro-bundle mimicking nervous system created by topology effect, Jeong GS, Chang JY, Park JS, Lee SA, Park D, Woo J, An H, Lee CJ, Lee SH, Mol Brain 2015 Mar 22;8(1):17. doi: 10.1186/s13041-015-0109-y. (2015)

     

    10.    Channel-mediated astrocytic glutamate modulates hippocampal synaptic plasticity by activating postsynaptic NMDA receptors, Park H, Han KS, Seo J, Lee J, Dravid SM, Woo J, Chun H, Cho S, Bae J, An H, Koh W, Yoon BE, Berlinguer-Palmini R, Mannaioni G, Traynelis SF, Bae Y, Choi SY, Lee CJ, Mol Brain 2015 Feb 3;8(1):7. (2015)

     

    11.    Glial GABA, synthesized by monoamine oxidase B, mediates tonic inhibition. Bo-Eun Yoon, JunsungWoo, Ye-Eun Chun, Heejung Chun, Seonmi Jo, Jin Young Bae, Heeyoung An, JooOkMin, Soo-Jin Oh, Kyung-Seok Han, Hye Yun Kim, Taekeun Kim, Young Soo Kim, Yong Chul Bae and C. Justin Lee, J Physiol. 2014 Sep 19. DOI: 10.1113 (2014)

     

    Awards

     

    1.        Oral presentation:

                                                                                i.              Direct cell reprogramming of reactive astrocytes into neurons in non-human primate, 2014 KU-KIST symposium

    2.        Poster Presentations:

                                                                                              i.             Transdifferentiation of scar-forming reactive astrocytes into functional neurons causes motor recovery after spinal cord injury, 2019 Korea Society for Gene and Cell Therapy

                                                                                            ii.             Cell direct reprogramming of reactive astrocytes into neurons in non-human primates. 2015 Glia Meeting of the Korean Society for Glia Research

  • Jaehun Lee
  • Postdoc
  • Neurodegenerative brain disease and scar forming astrocyte
  • cochleeibs.re.kr

Detail

  • Information
  • Research interest

    Neurodegenerative brain disease and scar forming astrocyte

     

    Education

    2004-2011 B.A. in Speech Language Pathology, Korean Nazarene University, Republic of Korea

    2012-2015 M.S. in Audiology, Catholic University of Daegu, Republic of Korea (advisor: Chul-Hee Choi)

    2016-2019 Ph.D. in Medicine (Otology), Dankook University, Republic of Korea (advisor: Jae Yun Jung)

     

     

    Research Experiences

    2022.01 – Present Postdoc, Center for Cognition and Sociality, Institute for Basic Science (ibs), Republic of Korea

    2020.08 - 2022.01 Research Professor, Medical Laser Research Center, Dankook University, Republic of Korea

    2015.03 - 2020.08 Research Scientist, Beckman Laser Institute Korea (BLIK), Dankook University, Republic of Korea

    2012.08 - 2015.02 Research/Teaching Assistant, Department of Audiology and Speech Language Pathology, Catholic University of Daegu, Republic of Korea

    2010.01- 2010.12 International Intern, Communication Disorder Center (CDC), Crotched Mountain Rehabilitation Center (CMRC), United States

     

    Awards and Honors

    2020 Best poster presentation, the 94th annual congress of Korean Society of Otorhinolaryngology-Head and Neck Surgery, Republic of Korea

    2019 Travel Award, the 42th Annual Midwinter Research Meeting of the Association for Research in Otolaryngology (ARO), United States

    2018 Best presentation award, 38th Aju otology symposium, Republic of Korea

    2017 Best presentation awards, 1st Otology basic research seminar, Korean Otological Society, Republic of Korea

    2018 Best presentation award, Korean Society for Laser Medicine and Surgery, Republic of Korea

    Grants

    2020.09 – 2023.05

    Title: Investigation on the role of Ca buffer protein in noise-induced cochlear synaptopathy, National Research Foundation of Korea (NRF), 180,000k KRW

    2019.09 – 2020.08

    Title: Neuroprotective effect of photobiomodulation mechanism study in secondary ganglion neuron degeneration model, National Research Foundation of Korea (NRF), 45,000k KRW

     

    Publications

    1. Lee JH, Carpena NT, Kim s, Lee MY, Jung JY, Choi JE. Photobiomodulation at a wavelength of 633 nm leads to faster functional recovery than 804 nm after facial nerve injury. Journal of Biophotonics. 2021 Jul 12:e202100159. (Front cover image)

    2. Kim JH, Jeon S, Choi HD, Lee JH, Bae JS, Kim N, Kim HG, Kim KB, Kim HR. Exposure to long-term evolution radiofrequency electromagnetic fields decreases neuroblastoma cell proliferation via Akt/mTOR-mediated cellular senescence. Journal of Toxicology and Environmental Health, Part A. 2021 Jul 3:1-2.

    3. Kim MT, Lee JH, Carpena NT, Lee MY, Chung PS, Jung JY. Estrogen replacement reduces hearing threshold shifts and cochlear hair cell loss after acoustic overexposure in ovariectomized rats. Clinical and Experimental Otorhinolaryngology. 2021 Feb;14(1):61. (co-first author)

    4. Lee JH, Lee MY, Choi JE, Jung JY. Auditory Brainstem Response to Paired Click Stimulation as an Indicator of Peripheral Synaptic Health in Noise-Induced Cochlear Synaptopathy. Frontiers in Neuroscience. 2021;14: 596670.

    5. Lee JH, Jung JY, Park I. A Gap Prepulse with a Principal Stimulus Yields a Combined Auditory Late Response. Journal of Audiology & Otology. 2020 Jul;24(3):149.

    6. Lee JH, Lee MY, Chung PS, Jung JY. Photobiomodulation using lowlevel 808 nm diode laser rescues cochlear synaptopathy after acoustic overexposure in rat. Journal of Biophotonics. 2019 Nov;12(11):e201900145.

    7. Choi JE, Lee JH, Chang SY, Lee MY, Jung JY. Clinical Implications of Poloxamer 407 as Packing Material in an Animal Model. Audiology and Neurotology. 2019;24(2):100-8.

    8, Lee JH, Kim S, Jung JY, Lee MY. Applications of photobiomodulation in hearing research: from bench to clinic. Biomedical Engineering Letters. 2019 Aug;9(3):351-8.

    9. Kim JH, Huh YH, Lee JH, Jung JY, Ahn SC, Kim HR. Early exposure to radiofrequency electromagnetic fields at 1850 MHz affects auditory circuits in early postnatal mice. Scientific Reports. 2019 Jan 23;9(1):1-0.

    10. Lee JH, Lee MY, Chung PS, Jung JY. Secondary degeneration of auditory neurons after topical aminoglycoside administration in a Gerbil model. Biomed Research International. 2018 Mar 1;2018.

    11. Lee MY, Bae SH, Chang SY, Lee JH, Kim SH, Ahn JC, Chung PS, Moy W, Jung JY. Photobiomodulation by laser therapy rescued auditory neuropathy induced by ouabain. Neuroscience Letters. 2016 Oct 28;633:165-73.

    12. Lee JH, Chang SY, Moy WJ, Oh C, Kim SH, Rhee CK, Ahn JC, Chung PS, Jung JY, Lee MY. Simultaneous bilateral laser therapy accelerates recovery after noise-induced hearing loss in a rat model. PeerJ. 2016 Jul 21;4:e2252.

     

  • Jea Kwon
  • Postdoc
  • Reactive astrocyte and sleep disorder
  • jeakwonibs.re.kr

Detail

  • Information
  • Jea Kwon, Ph. D. course

    Contact: jeakwon@ibs.re.kr (official) onlytojay@gmail.com (private)
    Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/?term=jea+kwon
    Github: https://github.com/jeakwon/

    EDUCATION
    [2007.03 ~ 2012.03] Full Scholarship Korea - Japan Joint Government Program
    [2008.04 ~ 2012.03] B.E. in Electrical and Electronic Systems at Saitama University, Japan
    [2013.08 ~ present] Ph.D. course, KU-KIST Graduate School of Converging Science and Technology in Korea University
    [2014.03 ~ 2018.11] Researcher, Center for Functional Connectomics, Korea Institute of Science and Technology (KIST), Republic of Korea
    [2017.03 ~ present] Technical Research Personnel (Mandatory military service in Republic of Korea)
    [2018.12 ~ present] Researcher, Center for Cognition and Sociality, Institute for Basic Science (IBS), Republic of Korea

    INTERESTS
    - Astrocyte-Neuron Interaction
    - Circadian Rhythm and Sleep
    - Synaptic Plasticity
    - Cognition, Human intelligence
    - Brain-inspired Artificial Intelligence
     
    Skills
    - Live cell/slice electrophysiology
    - Live cell/slice imaging
    - EEG/Circadian rhythm recording
    - Python/Matlab programing for data analysis (imaging, electrophysiology, behavior)
    - Python programing for machine learning


    PUBLICATIONS
    Ultrasonic Neuromodulation via Astrocytic TRPA1. Oh SJ, Lee JM, Kim HB, Lee J, Han S, Bae JY, Hong GS, Koh W, Kwon J, Hwang ES, Woo DH, Youn I, Cho IJ, Bae YC, Lee S, Shim JW, Park JH, Lee CJ. Curr Biol. 2019 Oct 21;29(20):3386-3401.e8. doi: 10.1016/j.cub.2019.08.021. Epub 2019 Oct 3.

    Tweety-homolog (Ttyh) Family Encodes the Pore-forming Subunits of the Swelling-dependent Volume-regulated Anion Channel (VRACswell) in the Brain. Han YE, Kwon J, Won J, An H, Jang MW, Woo J, Lee JS, Park MG, Yoon BE, Lee SE, Hwang EM, Jung JY, Park H, Oh SJ, Lee CJ. Exp Neurobiol. 2019 Apr;28(2):183-215. doi: 10.5607/en.2019.28.2.183. Epub 2019 Apr 30.

    Control of motor coordination by astrocytic tonic GABA release through modulation of excitation/inhibition balance in cerebellum. Woo J, Min JO, Kang DS, Kim YS, Jung GH, Park HJ, Kim S, An H, Kwon J, Kim J, Shim I, Kim HG, Lee CJ, Yoon BE. Proc Natl Acad Sci U S A. 2018 May 8;115(19):5004-5009. doi: 10.1073/pnas.1721187115. Epub 2018 Apr 24.

    Development of a Low-cost, Comprehensive Recording System for Circadian Rhythm Behavior. Kwon J, Park MG, Lee SE, Lee CJ. Exp Neurobiol. 2018 Feb;27(1):65-75. doi: 10.5607/en.2018.27.1.65. Epub 2018 Feb 28.

    Orai1 and Orai3 in Combination with Stim1 Mediate the Majority of Store-operated Calcium Entry in Astrocytes. Kwon J, An H, Sa M, Won J, Shin JI, Lee CJ. Exp Neurobiol. 2017 Feb;26(1):42-54. doi: 10.5607/en.2017.26.1.42. Epub 2017 Feb 9.

    The Ca2+-activated chloride channel anoctamin-2 mediates spike-frequency adaptation and regulates sensory transmission in thalamocortical neurons. Ha GE, Lee J, Kwak H, Song K, Kwon J, Jung SY, Hong J, Chang GE, Hwang EM, Shin HS, Lee CJ, Cheong E. Nat Commun. 2016 Dec 19;7:13791. doi: 10.1038/ncomms13791.

  • Moonsun Sa
  • Ph.D course (KU-KIST)
  • Neuron-Glia interaction, Reactive astrocytes and Obesity
  • moonsunibs.re.kr

Detail

  • Information
  • EDUCATION

    MAR 2014~ present     Ph.D. course, KU-KIST Graduate School of Converging Science and Technology, Seoul, Korea (Thesis advisor: Dr. Changjoon Justin Lee)

    MAR 2006~ FEB 2011   B.A. College of Life science & Biotechnology, Korea University, Seoul, Korea

     

    RESEARCH EXPERIENCE

    NOV 2018~ Present     Researcher, Center for Cognition and Sociality, Institute for Basic Science (IBS), Daejeon, Korea

    FEB 2014~ NOV 2018    Researcher, Center for Functional Connectomics, Korea Institute of Science and Technology (KIST), Seoul, Korea

     

    RESEARCH INTERSTS

    Neuron-glia interaction

    Reactive astrocytes in hypothalamus, Obesity and metabolism

    Learning and memory, ADHD


    EXPERIMENTAL TECHNIQUES

    Slice patch recording (Neuron), Cell patch (COS-7, HEK293T), Ca2+ Imaging

    Confocal microscope imaging, Immunohistochemistry, Immunocytochemistry

    Primary astrocyte culture, PCR, RT-PCR, DNA/RNA prep., Cloning

    Stereotaxic surgery, Open field test, Elevate plus maze, Passive avoidance test, Eight arm radial maze


    AWARDS

    AUG 2018        BEST PRESENTATION AWARD at 21st KSBNS Annual Meeting

                        (Poster title: GABA from Reactive Astrocytes in Hypothalamus via Monoamine Oxidase B Causes and Exacerbates Obesity)

    NOV 2016        Second Award at KIST-BSI Conference 2016

                        (Poster title: GABA from Reactive Astrocytes may Cause and Exacerbate Obesity)

    SEP 2016        Second Award at 2016 Converging Conference for KIST-School Ties

                        (Poster title: GABA from Reactive Astrocytes may Cause and Exacerbate Obesity)


    PUBLICATION

    1.   NaHye Lee*, Moonsun Sa*, Yu Ri Hong, C. Justin Lee†, and JaeHyung Koo†. Fatty Acid Increases cAMP-dependent Lactate and MAO-B-dependent GABA Production in Mouse Astrocytes by Activating a Gαs Protein-coupled Receptor. Experimental Neurobiology, 2018 Oct;27(5):365-376. doi: 10.5607/en.2018.27.5.365.


    2.   Jea Kwon, Heeyoung An, Moonsun Sa, Joungha Won, Jeong Im Shin, and C. Justin Lee. Orai1 and Orai3 in combination with stim1 mediate the  majority of store-operated calcium entry in astrocytes. Experimental Neurobiology, 2017 Feb;26(1):42-54. doi: 10.5607/en.2017.26.1.42.

     

  • Jungmoo Lee
  • Ph.D course (KU-KIST)
  • jmooibs.re.kr

Detail

  • Information
  • EDUCATION Undergraduate 2009.03 ~ 2013.02 Sungkyunkwan University in Korea Current status 2014.03 ~ KU-KIST Graduate School of Converging Science and Technology in Korea RESEARCH INTERESTS Stretch-activated TRPA1 channel activation mechanism TRPA1 channel and Amyotrophic Lateral Sclerosis (ALS) EXPERIMENTAL TECHNIQUES Electrophysiology: Astrocyte cell patch, Sniffer patch Imaging: Ca2+ imaging Molecular biology: Cloning, RT-PCR CONFERENCES and SYMPOSIUM 1. 2014 BSI symposium in Korea 2. 2015 The Korean Society for Glial Research POSTER PRESENTATION 1. A well-known antipsychotic drug trifluoperazine inhibits proliferation, migration and invasion of glioblastoma cells by overactivating IP3R1 and IP3R2 channels. The Korean Society for Glial Research. 2015

     

  • Sunpil Kim
  • Ph.D course (KU-KIST)
  • Neurobiology
  • spkimibs.re.kr

Detail

  • Information
  • EDUCATION

    - 2007.03 ~ 2014.02 : B.A. in Yonsei University

    - 2016.03 ~ Present : Ph.D Course (KU-KIST, Advisor: C. Justin Lee)

     

    RESEARCH EXPERIENCES

    - 2012.07 ~ 2013.06 Undergraduate Intern (Prof. Park in Yonsei University, Immunology)

    - 2014.03 ~ 2014.08 Undergraduate Intern (Prof. Lee in Yonsei University, Bioinformatics)

    - 2014.10 ~ 2016.02 Internship (Dr. C. Justin Lee's lab, Glioscience)

     

    PUBLICATIONS

    - Yong Kyoung Yoo, Jaekwang Lee, Jinsik Kim, Gangeun Kim, Sunpil Kim, Jeongyeon Kim, Heejung Chun, Jeong Hoon Lee, C. Justin Lee & Kyo Seon Hwang, Ultra-sensitive detection of brain-derived neurotrophic factor (BDNF) in the brain of freely moving mice using an interdigitated microelectrode (IME) biosensor, Scientific Reports, 2016.

     

    EXPERIMENTAL TECHNIQUES

    - Imaging:

      Acute brain slice imaging (Calcium, Fura-2 and various sensors)

      2-photon brain slice imaging

    - Behavior:

      Social behaviors (3-chamber test and five-trial social memory test)

      General behaviors (Open field test, novel object recognition and novel place recognition test)

      Fear-associated behavior (Passive avoidance test and contextual fear conditioning)

    - Electrophysiology:

      Patch clamping (Cultured cell and acute brain slice)

    - Molecular biology:

      Cloning, RT-PCR and Western blot

    - Primary astrocyte culture and microporation

    - Stereotaxic surgery :

      Guide cannulation (Microdialysis)

      Virus injection

    - Immunohistochemistry (IHC) for mouse

    - Microdialysis

     

    AWARDS

    - Outstanding presentation award (2018 5th SGFP Annual Conference)

  • Min-Woo Jang
  • Ph.D course (KU-KIST)
  • Glia-neuron interaction, gliovascular coupling
  • minwooleaibs.re.kr

Detail

  • Information
  • EDUCATION

     

    • 2010.03 ~ 2014.08 B.A. in Sookmyung Women’s University

    • 2015.03 ~ KU-KIST Graduate School of Converging Science and Technology, Korea University

     

    RESEARCH EXPERIENCES

     

    • 2012.01 ~ 2012.12 Undergraduate intern (Prof. Jonghoon Park, Sookmyung Women’s University)

    • 2013.06 ~ 2013.09 52nd National Undergraduate Symposium on Biology (Aging & Senescence)

     

    EXPERIMENTAL TECHNIQUES

     

    • Electrophysiology: Cell patch, Slice patch

    • Imaging: Calcium imaging, Intrinsic optical signal (IOS) imaging

    • Molecular biology: Cloning, RT-PCR, Western blot, Biotinylation, Co-immunoprecipitation

    • Cellular biology: Transfection, Microporation

    • Primary culture: Astrocyte cell culture, Cochlea tissue culture

    • Stereotaxic surgery (mouse)

    • Immunohistochemistry, Immunocytochemistry

     

    PUBLICATIONS

     

     

    1. Han K, Lee M, Lim HK, Jang MW, Kwon J, Lee CJ, Kim SG, Suh M. Excitation-inhibition imbalance leads to alteration of neuronal coherence and neurovascular coupling under acute stress. J Neurosci. 2020 Oct 20:JN-RM-1553-20. doi: 10.1523/JNEUROSCI.1553-20.2020. PMID: 33087471.

       

    2. Woo J, Jang MW, Lee J, Koh W, Mikoshiba K, Lee CJ. The molecular mechanism of synaptic activity-induced astrocytic volume transient. J Physiol. 2020 Jul 24. doi: 10.1113/JP279741. PMID: 32706443.

       

    3. Han YE, Kwon J, Won J, An H, Jang MW, Woo J, Lee JS, Park MG, Yoon BE, Lee SE, Hwang EM, Jung JY, Park H, Oh SJ, Lee CJ. Tweety-homolog (Ttyh) Family Encodes the Pore-forming Subunits of the Swelling-dependent Volume-regulated Anion Channel (VRACswell) in the Brain. Exp Neurobiol. 2019 Apr;28(2):183-215. doi: 10.5607/en.2019.28.2.183. Epub 2019 Apr 30. PMID: 31138989.

     

    AWARDS

     

    Oral Presentation:

    • 2017 Brain Science Institute Symposium (The novel channel, AUDITORIN discloses a new class of hearing loss, auditory gliopathy)

    Poster Presentation:

    • 2018 Glia Meeting of the Korean Society for Glia Research (Human speech perception by AUDITORIN (TMEM43) in cochlear glia)

    • 2019 7th SIPF-SIF International Workshop on: Structure and Function of Ion Channels and Transporters (AUDITORIN (TMEM43), A Novel Passive Conductance Channel of Cochlear Glia is Critical for Maintenance of Speech Discrimination)

  • Woojin Won
  • Ph.D course (KU-KIST)
  • Glia physiology, Neuroscience, Inflammation
  • wwjibs.re.kr

Detail

  • Information

  • EDUCATION 


    - 2009.03 ~ 2014.03: B.S. in Korea University, Seoul, Republic of Korea
    - 2015.03 ~ 2022.08: Ph.D course in KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, Republic of Korea

    ACADEMIC RESEARCH INTEREST

    - Neuroscience (Neuron-glia interaction)
    - Neurodegenerative diseases
    - Systemic inflammation
    - Reactive oxygen species (ROS)
    -Drug development
    - Post-traumatic stress disorder (PTSD)
    - Emotions


    EXPERIMENTAL TECHNIQUES 


    - Electrophysiology: Cell patch, Slice patch 
    - Imaging: Calcium imaging, Neurotransmitters, sensor probe
    - Immunohistochemistry, Immunocytochemistry
    - Molecular biology: Cloning, qRT-PCR, shRNA 
    - Cellular biology: Transfection, Microporation 
    - Astrocyte cell culture
    - Behavior test (mouse) 
    - Stereotaxic surgery (mouse, rat): virus injection, cannula surgery 
    - Drug screening assay (H2O2, MAOB etc.)
    - RNA-Sequencing


    AWARD and HONORS


    Oral Presentation award 
     - 2019 Korean Chemical Society, Division of Medicinal Chemistry; Best Presentation


    Poster Presentation award
     - 2018 Glia Meeting of the Korean Society for Glia Research
     - 2019 Cold Spring Harbor Asia (CSHA) meeting, Francis Crick Symposium-Transforming Neurosciences:
    Questions & Experiments
    - 2021 Korean Society for Brain and Neural Sciences (KSBNS); Best Presentation Award
    - 2022 Korean Society for Brain and Neural Sciences (KSBNS); Best Presentation Award
    - 2022 IBS-UNIST Symposium; Best Presentation Award


    PATENTS 


    Composition for prevention or treatment of rheumatoid arthritis (10-2020-0120924)


    NOVEL AMINOAROMATIC COMPOUNDS OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AND PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF NEURODEGENERATIVE DISEASES COMPRISING THE SAME AS AN ACTIVE INGREDIENT (10-2021-0155076)


    Prolonging lifespan with long-term administration of novel H2O2 scavenger (10-2022-0092661)

     

    PUBLICATION


    1. Won W, Choi HJ, Yoo JY, Kim D, Kim TY, Ju YH, Park KD, Lee H, Jung SY, Lee CJ. inhibiting peripheral and central MAO-B ameliorates both joint inflammation and cognitive impairment in rheumatoid arthritis. Exp Mol Med (in press)

     

    2. An H, Lee H, Yang S, Won W, Lee CJ, Nam MH. Adenovirus-induced Reactive Astrogliosis Exacerbates the Pathology of Parkinson's Disease. Exp Neurobiol. 2021 Jun 30;30(3):222-231. doi: 10.5607/en21013. PMID: 34045369; PMCID: PMC8278136.


    3. Kim TY, Jeon S, Jang Y, Gotina L, Won J, Ju YH, Kim S, Jang MW, Won W, Park MG, Pae AN, Han S, Kim ST, Lee CJ. Platycodin D, a natural component of Platycodon grandiflorum, prevents both lysosome- and TMPRSS2-driven SARS-CoV-2 infection by hindering membrane fusion. Exp Mol Med 53, 956–972 (2021).


    4. Chun H, Im H, Kang YJ, Kim Y, Shin JH,Won W, Lim J, Ju Y, Park YM, Kim S, Lee SE, Lee J, Woo J, Hwang Y, Cho H, Jo S, Park JH, Kim D, Kim DY, Seo JS, Gwag BJ, Kim YS, Park KD, Kaang BK, Cho H, Ryu H, Lee CJ. Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer's disease via H2O2- production. Nat Neurosci. 2020 Dec;23(12):1555-1566. doi: 10.1038/s41593-020-00735-y. Epub 2020 Nov 16. PMID: 33199896.


    5. Nam MH, Cho J, Kwon DH, Park JY, Woo J, Lee JM, Lee S, Ko HY, Won W, Kim RG, Song H, Oh SJ, Choi JW, Park KD, Park EK, Jung H, Kim HS, Lee MC, Yun M, Lee CJ, Kim HI. Excessive Astrocytic GABA Causes Cortical Hypometabolism and Impedes Functional Recovery after Subcortical Stroke.Cell Rep. 2020 Jul 7;32(1):107861. doi: 10.1016/j.celrep.2020.107861. Erratum in: Cell Rep. 2020 Jul 21;32(3):107975. PMID: 32640227.


    6. Nam MH*, Won W*, Han KS, Lee CJ. Signaling mechanisms of μ-opioid receptor (MOR) in the hippocampus: disinhibition versus astrocytic glutamate regulation. Cell Mol Life Sci. 2021 Jan;78(2):415-426. doi: 10.1007/s00018-020-03595-8. Epub 2020 Jul 15. PMID: 32671427.


    7. Heo JY, Nam MH, Yoon HH, Kim J, Hwang YJ, Won W, Woo DH, Lee JA, Park HJ, Jo S, Lee MJ, Kim S, Shim JE, Jang DP, Kim KI, Huh SH, Jeong JY, Kowall NW, Lee J, Im H, Park JH, Jang BK, Park KD, Lee HJ, Shin H, Cho IJ, Hwang EM, Kim Y, Kim HY, Oh SJ, Lee SE, Paek SH, Yoon JH, Jin BK, Kweon GR, Shim I, Hwang O, Ryu H, Jeon SR, Lee CJ. Aberrant Tonic Inhibition of Dopaminergic Neuronal Activity Causes Motor Symptoms in Animal Models of Parkinson's Disease. Curr Biol. 2020 Jan 20;30(2):276-291.e9. doi: 10.1016/j.cub.2019.11.079. Epub 2020 Jan 9. PMID: 31928877.

     

     

    8. Min-Ho Nam, Kyung-Seok Han, Jaekwang Lee, Woojin Won, Wuhyun Koh, Jin Young Bae, Junsung Woo, Jayoung Kim, Elliot Kwong, Tae-Yong Choi, Heejung Chun, Seung Eun Lee, Sang-Bum Kim, Ki Duk Park, Se-Young Choi, Yong Chul Bae, C. Justin Lee. Activation of Astrocytic μ-Opioid Receptor Causes Conditioned Place Preference. Cell reports. Volume 28, Issue 5, 30 July 2019, Pages 1154-1166.e5.

     

     

    - Ph.D course (KU-KIST)


    -Glia-neuron interaction, Neurodegeneration and Neuroinflammation.


    - wwj@ibs.re.kr

     

  • Min Gu Park
  • Ph.D course (KU-KIST)
  • mgparkibs.re.kr

Detail

  • Information
  • Educational background

    - 2016/09 ~ Present, Ph.D. candidate in KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, Republic of Korea (Advisor: C. Justin, Lee)

    - 2010/03 ~ 2016/08, B.E. in Biomedical engineering, Korea University, Seoul, Republic of Korea

    - 2012/05 ~ 2014/02, KATUSA soldier program (U.S. Army Garrison Casey, South Korea)

     

    Research Experiences

    - 2014/09 ~ 2016/05, Undergraduate internship, Prof. Sang-Hoon Lee’s iBML lab, Korea University.

      

    Field of interest

    - Targeting astrocytes as a novel therapeutic target for treating epilepsy.

    - Physiological and pathological function of TRIM9 in astrocytes.

    - Modulation of synaptic transmission by astrocytes.

    - Mechanosensitive calcium channels on radial glial cells.

     

    EXPERIMENTAL TECHNIQUES

    - Calcium imaging, GABA imaging

    - Behavior test (Passive avoidance test, Open field test, novel object recognition and novel place recognition test)

     - Electrophysiology: Patch clamping (Cultured cell and acute brain slice), Field recording

    - Molecular biology: Cloning, RT-PCR and Western blot

    - Primary astrocyte culture

    - ICC and IHC

    - Virus injection

     

    Publications

    -Flow Shear Stress Enhances the Proliferative Potential of Cultured Radial Glial Cells Possibly Via an Activation of Mechanosensitive calcium channel. Park MG, Jang H, Lee SH, Lee CJ, Exp Neurobiol 2017 Apr;26(2):71-81. (2017)

    - Development of a low-cost, comprehensive recording system for circadian rhythm behavior. Jea Kwon, Min Gu Park, Seung Eun Lee, and C. Justin Lee. Exp Neurobiol. 2019 Feb;28(1):30-42 (2018)

    - Pharmacological Dissection of Intrinsic Optical Signal Reveals a Functional Coupling between Synaptic Activity and Astrocytic Volume Transient. Woo J, Han YE, Koh W, Won J, Park MG, An H, Lee CJ, Exp Neurobiol 2018 Feb 27;27(1):65-75; (2018)

    - Tweety-homolog (Ttyh) Family Encodes the Pore-forming Subunits of the Swelling-dependent Volume-regulated Anion Channel (VRACswell) in the Brain. Han YE, Kwon J, Won J, An H, Jang MW, Woo J, Lee JS, Park MG, Yoon BE, Lee SE, Hwang EM, Jung JY, Park H, Oh SJ, Lee CJ, Exp Neurobiol. 2019 Apr;28(2):183-215 (2019)

     

    Awards

    - 2017/03 ~ Present, Global Ph.D. Fellowship program from National Research Foundation of Korea

     

  • Young-Min Park
  • Ph.D course (UST)
  • dydalsqkr94gmail.com

Detail

  • Information
  • EDUCATION

    -2013.03 ~ 2017.08 B.A in Seoul National University

    -2017.09 ~ Present Ph.D candidate in University of Science and Technology(UST)

     

    RESEARCH EXPERIENCE

    -2016.06 ~ 2016.08 Students intern researcher program(학생인턴연구원) in School of Medicine, Seoul National University.

    -2017.03 ~ 2017.08 Undergraduate intern in Dr. C. Justin Lee lab, Korea Institute of Science and Technology (KIST)

     

    EXPERIMENTAL TECHNIQUES

    -Molecular biology: Cloning, RT-PCR

    -Cellular biology: Transfection, Microporation

    -Astrocyte cell culture (+ Long-term culture)

    -Stereotaxic surgery (mouse)

    -Immunohistochemistry

    -Imaging: Calcium imaging in vitro

    -Electrophysiology: Cell patch, Slice patch

    -Behavior test: Passive avoidance test, Open field test, Novel object (Place) recognition test, Context fear conditioning test, Elevated plus maze test, Forced swim test

     

    AWARDS

    -Poster presentation

    2018 Glia Meeting of the Korean Society for Glia Research (Charcterization of hGFAP-CreERT2 [Tg(GFAP-Cre/ERT2)13Kdmc] in various brain region)

     

    PUBLICATION

    -Koh, W., Park, Y. M., Lee, S. E., & Lee, C. J. (2017). AAV-mediated astrocyte-specific gene expression under human ALDH1L1 promoter in mouse thalamus. Experimental neurobiology, 26(6): 350-361.

    - Park, Y. M., Chun, H., Shin, J. I., & Lee, C. J. (2018). Astrocyte Specificity and Coverage of hGFAP-CreERT2 [Tg (GFAP-Cre/ERT2) 13Kdmc] Mouse Line in Various Brain Regions. Experimental neurobiology, 27(6): 508-525.

  • Hyunji Kang
  • Ph.D course (UST)
  • hjkibs.re.kr

Detail

  • Information
  • Education

    PhD course, Department of Basic Science, IBS School in University of Science and Technology (UST), KOREA (2017.03-present)

    M.S, Department of Mathematics, Konkuk University, KOREA (2013.09-2015.08)

    B.S, Department of Mathematics, Konkuk University, KOREA (2009.03-2013.08)

     

    Research experiences

    2015.07~2016.08 rare cancer branch in National Cancer Center (NCC)

    2016.10~2018.05 in Korea Institute of Radiological and Medical Sciences (KIRAMS)

     

    Awards

    2015 Poster Presentation Award from Korean Society for Industrial and Applied Mathematics.

    (Mathematical modeling of Glioblastoma cell type specific about FLIP-induced TRAIL resistance)

    2014 Poster Presentation Award from Korean Society of Mathematical Biology.

    (Mathematical modeling of the AKT-mTOR-p70S6K pathway in regulation of the control of FLIP and TRAIL-induced apoptosis in cancer)

     

    Scholarships

    2018-1st Assistant scholarship from University of Science and Technology (UST), Korea

    2013-2nd ~2015-1st Graduate teaching Scholarship from Konkuk University, KOREA.

  • Mridula Neeraj Kumar Bhalla
  • Ph.D course (UST)
  • bmridula158gmail.com

Detail

  • Information
  • MRIDULA NEERAJ KUMAR BHALLA – CV

    Contact details - +82-010-7286-9608, +91 97667-11187 ; bmridula158@ibs.re.kr

    Date of Birth                          :               15th August 1996

    Nationality                              :                Indian

    Research Interest

    Astrocytes and CNS demyelination, Astrocytes in aging

     

    Education

     

    Mar. 2020-present

     

     

    Aug 2014 - May. 2019

    Doctoral Course at IBS School, University of Science and Technology, South Korea

    Principal investigator: Dr. C. Justin Lee

     

    Masters of Science (Integrated), Pune University, India

    Major : Biotechnology

     

    Research Experience

     

    May. 2016 - Oct. 2018

     

     

     

     

     

     

     

    May. 2017 - Jul. 2019

     

     

     

     

     

    Dec. 2018 – Apr 2019

    Undergraduate Student Researcher at Institute of Bioinformatics and Biotechnology, Pune University

    Dr. Tuli Dey’s laboratory

    Studying on breast cancer 3-D tumour spheroids, tumour immune microenvironment and drug synergistic action

     

    IAS-INSA-NASI Summer Research Fellow at Rajiv Gandhi Center for Biotechnology, Kerala

    Dr. M. R. Pillai’s laboratory

    A training in techniques for the monitoring of HPV vaccination studies
     

    Visiting Intern at Daegu Gyeongbuk Institute of Science and Technology, South Korea

    Dr. Jinsoo Seo’s laboratory

    Examination of pathological phenotypes in Neural Progenitor Cells with Alzheimer’s disease-associated genetic variants

     

    Publication

     

    Jung, Y., Kim, Y., Bhalla, M., Lee, S., & Seo, J. (2018). Genomics: New Light on Alzheimer’s Disease Research. International journal of molecular sciences19(12), 3771.

     

     

     

    Research Techniques

     

    Mouse Surgery

    Stereotaxic virus injection, oral injection, primary cell culture

    Animal Cell Culture techniques

     

    3-D spheroid fabrication, iPS cell culture techniques

    Histology

    Basic immunostaining and confocal imaging techniques, Lattice SIM imagine

    Molecular Work

    Genotyping, DNA prep, RNA prep, qRT PCR, microbial transformation, enzymatic assays, ELISA, Luminex and multiplex PCR, protein purification and analysis

    Imaging

    Calcium ion imaging with FURA-2 at astrocyte cell culture, Intrinsic Optical Signal Imaging, Potassium ion imaging in primary cultured astrocytes using APG1

    Electrophysiology

    Cell patch and slice patch, sniffer patch for detection of released GABA

     

    Awards, Honors, and Scholarships

     

    IAS-INSA-NASI Summer Research Fellowship, 2017

     

    Curricular and Extracurricular experience

     

    Participated in the National Symposium on “Recent Trends in Epigenetics” at  Pune University (2016).

    Attended the “One Day Symposium on Biosafety” at Rajiv Gandhi Centre for Biotechnology (RGCB), Thiruvananthapuram (2017).

    Attended the “One Day Satellite Symposium on Neuroscience” (sponsored by the IBRO-APRC-Associate School of Neuroscience) at Pune University (2018).

    Chairperson of the Indo-Korean Culture Group, Pune (August 2018 – September 2019)

    Content writer at WittyPen (November 2015 – March 2017)

     

     

  • Abdelrahman Alkahwaji
  • Ph.D course (UST)
  • abdelrahmanalkahwajigmail.com

  • JinHyeong Joo
  • Ph.D course (UST)
  • jhjooibs.re.kr

Detail

  • Information
  • JinHyeong Joo, Integrated Ph.D course

    E-mail : jhjoo@ibs.re.kr (official) / wnwlsgud0430@gmail.com (private)

    Tel : +82) 010-6847-3680

     

    RESEARCH INTEREST

    • Neurodegenerative Disease & Memory in Astrocyte

       

    EDUCATION

    • [2021.01 ~ Present] Integrated Ph.D course at Univesity of Science & Technology (UST), Korea,

    • [2021.01 ~ Present] Dr. C. Justin Lee’s Lab, Institute of Basic Science (IBS) School of UST,

    • [2014.03 ~ 2019.02] B.E. in Ajou University, Applied Chemistry & Biological Engineering

       

    RESEARCH EXPERIENCES

    • [2020.03 ~ 2020.11] Reseacher in Immunobiome, Inc. in POSTECH biotech center, Pohang

    • [2019.08. ~ 2019.08] Internship in POSTECH IRT lab. (Shin Hyeog Im’s lab), Pohang

    • [2018.07 ~ 2018.09] Internship in Purification process in CJ 제일제당 laboratory, Suwon

     

    RESEARCH TECHNIQUES

    Mouse handling

    • Oral gavage, i.p./s.c. injection, Blood collection (Heart, Orbital), Manual heart perfusion, mouse breeding

    Behavior Test

    • Sociability test, Social novelty test via 3-chamber arena, Marble burying test for evaluate repetitive behavior

    Molcular work

    • DNA / RNA prep, Gel electrophoresis, PCR, qRT-PCR, genotyping,

    Cell work

    • FACS

     

  • Joon-ho Kwon
  • Ph.D course
  • jhkwonibs.re.kr

Detail

  • Information
  • Joon-Ho Kwon

    Curriculum Vitae ( Updated: Feb 25, 2022 )

    IBS ( Institute for Basic Science )

    Center for Cognition and Sociality

    55, Expo-ro, Yuseong-gu, Daejeon, 34126 Republic of Korea
    Mobile : +82-10-4189-9405

    Work Email: kwonjoonho@unist.ac.kr

     

    Education

    Feb. 2015              Chonnam National University                                                                                                          Gwangju, Korea

                                     Department of Biological Sciences

                                     B.S. in Biological Sciences

     

    Feb. 2017              Korea University                                                                                                                                        Seoul, Korea 

                                     Division of Life Sciences

                                     Thesis: Physiological interaction between copper and zinc in aspergillus fumigatus.

                                     Advisor: Prof. Cheol-Won Yun

                                     M.S. in Life Sciences

     

    Mar. 2022             UNIST (Ulsan National Institute of Science and Technology)                                                          Ulsan, Korea

    ~ Present               Department of Biomedical Engineering

    Co-Advisor: Dr. C. Justin Lee, Prof. Yoon-Kyoung Cho

    Ph.D. course

         

     

    Professional Training

    1. Master’s student, Korea University, Laboratory of  Molecular Microbiology, ( Jan. 2015 ~ Dec. 2016 )

    2. Technical Research Personnel, Seoul National University College of Medicine, Laboratory of Molecular Imaging and Therapy ( Jan. 2017 ~ Mar. 2020 )

    3. Researcher, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Infection and Immunity Research Laboratory ( Apr. 2020 ~ Jun. 2021 )

    4. Researcher, Institute for Basic Science (IBS), Cognitive Glioscience group, Director: Dr. C. Justin Lee’s Lab, Center for Cognition and Sociality ( Jul. 2021 ~ Feb. 2022 )

    5. Ph.D. Student,UNIST-IBS Neuroscience scholarship ( Mar. 2022 ~ Present )

     

    Publications (SCI only)

    1. Kim, M. J., Lee, C. H., Lee, Y., Youn, H., Kang, K. W., Kwon, J. H, ... & Chung, J. K. (2019). Glucose-6-phosphatase Expression–Mediated [18 F] FDG Efflux in Murine Inflammation and Cancer Models. Molecular imaging and biology, 21(5), 917-925.

    2. Kang, S., Seo, H., Moon, H. S., Kwon, J. H., Park, Y. S., & Yun, C. W. (2020). The Role of Zinc in Copper Homeostasis of Aspergillus fumigatus. International journal of molecular sciences, 21(20), 7665.

       

    Conferences (Talk/Poster)

    1. Joon-Ho Kwon, Cheol-Won Yun, "Physiological interaction between copper and zinc in aspergillus fumigatus", International Meeting of the Federation of Korean Microbiological Societies (2016) – poster

       

       

    Honors and Prizes

    Month/Year        Title                                                                                          Institution                              

    03/2015-09/2015    BK21 PLUS Scholarship (National Funding for Life Sciences)       Korea University

    09/2015-09/2016    Teaching Assistant Scholarship                                                         Korea University

     

    Skills and Techniques

    General mouse works ( Organ dissection, maintenance, genotyping ), Cell culture (  Fungi, Various cancer cells, primary Thyroid cancer cells ), Cloning, Transfection, Transduction, PCR, Northern blot, RT-qPCR, Western blot, Pull-down assay, Luciferase assay, Cryosection and IHC( Immunohistochemistry ), IF( immunofluorescence ), Confocal Microscopy, Tumor ( Breast, Brain ) modeling, Stereotaxic injection, Small animal imaging test ( PET/CT, IVIS ), FACS, ICP-OES.

     

  • Yoo Sung KIM
  • Ph.D course
  • astralkim41naver.com

  • Jiwoon Lim
  • Master's Course
  • 17limjwoongmail.com

Detail

  • Information
  • Jiwoon Lim

    Telephone: +82-10-9187-6930

    Email: 17limjwoon@ibs.re.kr

     

    Research Interest

    Astrocyte’s role in synapse, memory, and disease

     

    Education

    Sep. 2020-present

     

     

    Mar. 2013-Feb. 2019

    Integrated Course at Institute of Basic Science

    Principal investigator: Dr. C. Justin Lee

     

    Bachelor of Science and Arts at Korea University

    First major: Life Sciences

    Second major: Psychology

     

    Research Experience

    Feb. 2019 - Aug. 2019

     

     

     

     

    Sep. 2017 - Sep. 2019

     

     

     

    Dec. 2014 - June 2015

    Research Assistant at Institute of Basic Science

    Dr. C. Justin Lee’s laboratory

    Studying on reactive astrocyte, Alzheimer’s disease & storage operated calcium entry system

     

    Internship at Korea Institute of Science and Technology

    Dr. C. Justin Lee’s laboratory

    Studying on reactive astrocyte & Alzheimer’s disease

     

    Internship program of Korea University

    Prof. Bongjune Yoon’s laboratory

    Setting of CrisprCas9 system & learning mouse surgery and molecular work

     

    Publication

    Chun, H., Kim, Y., Kang, Y., Im, H., Shin, J., Won, W., Lim, J., Ju, Y., Park, Y., Kim, S., Lee, J., Woo, J., Hwang, Y., Jo, S., Wetzel I., Park, J., Kim, D., Kim, D., Gwag, B., Kim, Y., & Lee, C J. (2020). Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer's disease via excessive H2O2-production.

    Nature Neuroscience

     

    Kim, W., Won, S. Y., & Yoon, B. (2019). CRMP2 mediates GSK3β actions in the striatum on regulating neuronal structure and mania-like behavior. Journal of Affective Disorders245, 1079-1088.

    In acknowledgement

     

    Chun, H., An, H., Lim, J., Woo, J., Lee, J., Ryu, H., & Lee, C. J. (2018). Astrocytic proBDNF and tonic GABA distinguish active versus reactive astrocytes in hippocampus. Experimental Neurobiology, 27(3), 155-170.

     

    Poster Exhibition

    Lim, J.*, Chun, H.*, Won, J., Park, Y. M., & Lee, C. J. (2019). Mao-b inhibition reduces astrogliosis and transforms reactive astrocytes into active astrocytes under pathological conditions. International Brain Research Organization, Daegu, Korea of Republic

    Lim, J.*, Jee, S., Kwon J., Sa M. & Lee, C. J. (2020). Trifluoperazine (TFP) elevates intracellular Ca2+ level and maintains the open state of the store-operated calcium entry (SOCE) in astrocyte. The Korean Society for Brain and Neural Sciences, Seoul, Korea of Republic

     

     

    Research Techniques

    Mouse Surgery

    Perfusion, stereotaxic virus injection, IP injection, oral injection, blood prep from heart, primary cell culture

    Behavior Test

     

    Open field test, passive avoidance test, contextual fear conditioning, radial arm maze, novel place recognition, rotarod test, tactile discrimination test

    Histology

    Cryosection, IHC, controlling confocal imaging system and analyzing (Image J & IMARIS)

    Molecular Work

    Genotyping, DNA prep, RNA prep, gel electrophoresis, PCR, qRT PCR

    Calcium Imaging

    Calcium ion imaging with FURA-2 at astrocyte cell culture

    Electrophysiology

    Cell patch and slice patch

    Microdialysis

    Extracting CSF from mouse brain and analyzing endogenous molecule

     

    Awards, Honors, and Scholarships

    Outstanding Intern Award

    Internship program of the University of Science and Technology

     

    Feb. 2018

  • Yejin Seong
  • Master's Course
  • sungyejinibs.re.kr

  • Woo Suk ROH
  • Master's Course
  • zoo9689gmail.com

  • Jong Min KIM
  • Master's Course
  • josephkim0331gmail.com

  • Sung Eun Lee
  • Researcher
  • seleeibs.re.kr

CV

CV

CV

CV

CV

CVDetail

  • Information
  • ◆ Address
    Department of New Biology/DGIST, Center for Plant Senescence and Life History/IBS, Techno Jungang-daero 333, Hyeongpung-myun, Daegu 711-873, Republic of Korea

    ◆ E-mail

    - jkwak@dgist.ac.kr

    - jkwak@umd.edu

    ◆ Education

    - Ph. D 1997 Department of Life Sciences, POSTECH, Korea

    - M. S 1993 Department of Life Sciences, POSTECH, Korea

    - B. S 1987 Department of Biochemistry, Yonsei University, Korea

    ◆ Professional Experience

    - 01/2014 – present: Associate Professor, Department of New Biology , DGIST, Republic of Korea

    - 01/2014 – present: Group Leader, Center for Plant Senescence and Life History Institute for Basic Science, Republic of Korea

    - 01/2014 – present: Adjunct Professor, Department of Cell Biology and Molecular Genetics University of Maryland, College Park

    - 08/2010 - 01/2014: Associate Professor. Department of Cell Biology and Molecular Genetics University of Maryland, College Park

    - 07/2010 – present: Affiliate Associate Professor, Department of Plant Science and Landscape Architecture University of Maryland, College Park

    - 06/2010 - 05/2013: Adjunct Associate Professor, Department of Plant Molecular Systems Biotechnology Crop Biotech Institute. Kyung Hee University, Republic of Korea

    - 08/2003 - 07/2010: Assistant Professor, Department of Cell Biology and Molecular Genetics University of Maryland, College Park

    - 07/2002 - 08/2003: Senior Research Associate, Division of Biological Sciences, University of California, San Diego

    - 05/1997 - 06/2002: Postdoctoral Fellow of Human Frontier Science Program & Korea Research Foundation. Division of Biological Sciences, University of California, San Diego

    - 12/1988 - 02/1991: Research Fellow, Center for Pharmaceutical Research, Dae Woong Pharmaceutical Inc., Korea

  • Sungkyu Shaun Park (박성규)
  • Ph.D. Student
  • Research Interests: Data analysis and machine learning on mental health domains
  • shaun.parkkaist.ac.kr
  • http://shaun.kr/

CVDetail

  • Information
  • Data Science Laboratory

    Graduate School of Culture Technology

    Korea Advanced Institute of Science and Technology (KAIST)

  • Jiwan Jeong (정지완)
  • Ph.D. Student
  • Research Interests: Online news comment, opinion dynamics, online human behavior
  • jiwanjeonggmail.com
  • http://an.kaist.ac.kr/~jiwan

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  • Advanced Networking Laboratory

    School of Computing

    Korea Advanced Institute of Science and Technology (KAIST)

  • Jaeheon Kim (김재헌)
  • Research Interests: Natural Language Processing, Hate Speech, Machine Learning
  • heon9618gmail.com

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  • Data Science Laboratory

    School of Computing

    Korea Advanced Institute of Science and Technology (KAIST)

  • Hyeonho Song (송현호)
  • Research Interests: Online community data, Machine learning
  • hyun78kaist.ac.kr

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  • Data Science Laboratory

    School of Computing

    Korea Advanced Institute of Science and Technology (KAIST)

  • Hyunji Cha (차현지)
  • hyunji3190kaist.ac.kr

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  • Data Science Laboratory

    Software Graduate Program in School of Computing

    Korea Advanced Institute of Science and Technology (KAIST)

  • Jeongwook Kim (김정욱)
  • Research interests: User network analysis of social networking service (SNS), Korean NLP
  • captainfoxkaist.ac.kr
  • http://jeongwookie.github.io/

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  • Data Science Laboratory

    School of Computing

    Korea Advanced Institute of Science and Technology (KAIST)

  • Donghyun Ahn (안동현)
  • Research Interests: Geographic Information Systen(GIS), Computer Vision, Data Engineering
  • segaukwagmail.com

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  • Data Science Laboratory

    School of Computing

    Korea Advanced Institute of Science and Technology (KAIST)

  • Sungwon Han (한성원)
  • Research Interests: Computer vision, Deep learning, Deep embedding learning
  • lion4151kaist.ac.kr

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  • Data Science Laboratory

    School of Computing

    Korea Advanced Institute of Science and Technology (KAIST)

  • Jie Bian
  • cheop.byeonkaist.ac.kr

Detail

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  • Data Science Laboratory

    School of Computing

    Korea Advanced Institute of Science and Technology (KAIST)

  • Sun Geng
  • sungengkaist.ac.kr

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  • Data Science Laboratory

    School of Computing

    Korea Advanced Institute of Science and Technology (KAIST)

  • Taegyun Kim (김태균)
  • Research Interests: NLP for social science
  • jgdgj223gmail.com

  • Youngin Lee (이영인)
  • Research Interests: Application of NLP for social media and online news
  • antagonistkaist.ac.kr

  • Pyung Ok Lim
  • Professor
  • +82-53-785-1830
  • polimdgist.ac.kr

Detail

  • Information
  •  

    Research Interests

    Aging and programmed cell death in plants
    RNA-based regulation of leaf aging
    Synthetic genetics-based aging reprogramming

     

     

    ◆ Education

    1991, Michigan State University, Ph. D. in Genetics
    1985, Sogang University, M.S. in Biology
    1982, Sognag University, B. S. in Biology

     

    ◆ Professional Experience

    2012.09 - Present : Associate Professor, DGIST, Korea
    2005.03 - 2012. 08 : Assistant Professor, Associate Professor, Jeju National University

     

    Laboratory for Complex Biology

     

    Introduction to Research

    Aging in leaves is critical for plant’s fitness as nutrient relocalization from leaves to reproducing seeds is achieved through this process.
    Aging process in plants involves a coordinated action at the cellular, tissue, organ, and organism levels under the control of a highly regulated genetic program.
    We are taking systems biology approach to obtain insights into age-associated complex regulatory networks and understand the aging process in leaves.
    Synthetic genetic approaches are also taken to reprogram leaf aging based on the key regulatory network for increased biomass.
     

     

     

     

    Research Publication(selected)

    1. Kang HG, Kim J, Kim B, Jeong H, Choi SH, Kim EK, Lee HY, Lim PO (2011) Overexpression of FTL1/DDF1, an AP2 transcription factor, enhances tolerance to cold, drought, and heat stresses in Arabidopsis thaliana. Plant Science 180(4):634-641.
    2.  Woo HR, Kim JH, Kim JY, Kim JS, Lee U, Song IJ, Kim JH, Lee HY, Nam HG, Lim PO (2010) The RAV1 transcription factor positively regulates leaf senescence in  Arabidopsis. J Exp Bot. 61(14):3947–3957.
    3.  Lim PO, Lee IC, Kim J, Kim HJ, Ryu JS, Woo HR, Nam HG (2010) Auxin response factor 2 (ARF2) plays a major role in regulating auxin-mediated leaf longevity. J Exp Bot. 61(5):1419-1430.
    4.  Kim JH, Woo HR, Kim J, Lim PO, Lee IC, Choi SH, Hwang D, Nam HG (2009) Trifurcate feed-forward regulation of age-dependent cell death involving miR164 in Arabidopsis. Science. 323:1053-1057.
    5.  Lim PO, Kim Y, Breeze E, Koo JC, Woo HR, Ryu JS, Park DH, Beynon J, Tabrett A, Buchanan-Wollaston V, Nam HG. (2007) Overexpression of a chromatin architecture-controlling AT-hook protein extends leaf longevity and increases the post-harvest storage life of plants. Plant J. 52(6):1140-53.

     

    Invited Review Articles

    1.  Lim PO et al. (2007) Leaf senescence. Annu Rev Plant Biol. 58:115-36
    2.  Lim PO et al. (2003) Molecular genetics of leaf senescence in Arabidopsis. Trends in Plant Science 8:272-278.

     

    Patents(selected)
    1. Nam HG, Lim PO, Cho SH, ORE7, Gene controlling life span of leaves in plants and method for controlling life span of plants using the same. PCT/KR02/01578, China 02816505.5, CN 1547589A, Europe 02758930.8, EP1 436 324, Australia 02 758 930.8, USA 10/487,225, US-2005-0055745-A1, Reg No. 7,060,875

  • Hye Ryun Woo
  • Professor
  • +82-53-785-1831
  • hrwoodgist.ac.kr

Detail

  • Information
  • Research Interests

     Genome biology
     Epigenomics in plants
     Plant senescence

     

     

    ◆ Education

    2002: POSTECH (Ph.D. in Life Science)
    1999: POSTECH (M.S. in Life Science)
    1997: POSTECH (B.S. in Life Science)

     

    ◆ Professional Experience

    2013~present: Assistant Professor, DGIST, Korea 
    2009~2012: Assistant Professor, Dept. of Biology, Chungnam National University, Korea

     

    Major in New Biology

    Introduction to Research

    Multi-dimensional analysis of Arabidopsis transcriptome leaf across the lifespan
    Epigenomic analysis of Arabidopsis leaf lifespan

     

     

     Research Publication(selected)

    1. Yoonkang Hur, Jin Hee Kim, Dong-Joon Lee, Kyung Min Chung, and Hye Ryun Woo. Overexpression of AtCHX24, a member of the cation/H+ exchangers, accelerates leaf senescence in Arabidopsis thaliana (2012). Plant science 183, 175-182.
    2. Tae Hee Lee, Young Ran Kim, Joon Haeng Rhee, Jin-Hong Kim, Hye Ryun Woo, and Kyung Min Chung. Characterization of monoclonal antibodies targeting the RtxA1 toxin of Vibrio vulnificus (2011). Process Biochem 46, 1500-1508.
    3. Hye Ryun Woo, Jin Hee Kim, Junyoung Kim, Jeongsik Kim, Ung Lee, In-Ja Song, Jin-Hong Kim, Hyo-Yeon Lee, Hong Gil Nam and Pyung Ok Lim. The RAV1 transcription factor positively regulates leaf senescence in Arabidopsis (2010). J Exp Bot. 61(14), 3947-3957.
    4. Pyung Ok Lim, In Chul Lee, Junyoung Kim, Hyo Jung Kim, Jong Sang Ryu, Hye Ryun Woo* and Hong Gil Nam*. Auxin response factor 2 (ARF2) plays a major role in regulating auxin-mediated leaf longevity (2010). J Exp Bot. 61(5), 1419-1430. (*Corresponding authors)
    5. Jin Hee Kim*, Hye Ryun Woo*, Jeongsik Kim, Pyung Ok Lim, In Chul Lee, Seung Hee Choi, Daehee Hwang and Hong Gil Nam. Trifurcate feed-forward regulation of age-dependent cell death involving miR164 in Arabidopsis (2009). Science 323, 1053-1057. (*These authors contributed equally to this work.)